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    Ube2k ubiquitin-conjugating enzyme E2K [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289623, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ube2kprovided by RGD
    Official Full Name
    ubiquitin-conjugating enzyme E2Kprovided by RGD
    Primary source
    RGD:1311626
    See related
    Ensembl:ENSRNOG00000027088 AllianceGenome:RGD:1311626
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lig; Hip2; Hypg; E2-25k
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity; ubiquitin protein ligase binding activity; and ubiquitin-ubiquitin ligase activity. Acts upstream of or within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Predicted to be located in cytoplasm and filopodium tip. Predicted to be active in nucleus. Orthologous to human UBE2K (ubiquitin conjugating enzyme E2 K). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 175.1), Kidney (RPKM 123.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ube2k in Genome Data Viewer
    Location:
    14p11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (43011681..43077825, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (42658016..42718899, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (44289247..44348691, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene PDS5 cohesin associated factor A Neighboring gene U6 spliceosomal RNA Neighboring gene ribosomal protein L14 like 2 Neighboring gene ribosomal protein lateral stalk subunit P2 like 3 Neighboring gene small integral membrane protein 14 Neighboring gene UDP-glucose 6-dehydrogenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. E2-25K/Hip-2 regulates caspase-12 in ER stress-mediated Abeta neurotoxicity. Song S, et al. J Cell Biol, 2008 Aug 25. PMID 18710920, Free PMC Article
    2. Characterization of a novel ubiquitin-conjugating enzyme that regulates beta1,4-galactosyltransferase-1 in embryonic stem cells. Wassler MJ, et al. Stem Cells, 2008 Aug. PMID 18511602
    3. Expression of TMEM16 paralogs during murine embryogenesis. Rock JR, et al. Dev Dyn, 2008 Sep. PMID 18729231
    4. E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages. Christensen DE, et al. Nat Struct Mol Biol, 2007 Oct. PMID 17873885
    5. The ubiquitin E3 ligase MARCH7 is differentially regulated by the deubiquitylating enzymes USP7 and USP9X. Nathan JA, et al. Traffic, 2008 Jul. PMID 18410486, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-ubiquitin ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to interferon-beta ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in free ubiquitin chain polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in filopodium tip ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme E2 K
    Names
    huntingtin interacting protein 2
    ubiquitin-conjugating enzyme E2-25K
    ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)
    NP_001099476.1
    XP_038947644.1
    XP_038947645.1
    XP_063128995.1
    XP_063128996.1
    XP_063128997.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106006.1 → NP_001099476.1  ubiquitin-conjugating enzyme E2 K

      See identical proteins and their annotated locations for NP_001099476.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473981
      UniProtKB/TrEMBL
      A0A8I6AV01, A6JDD4
      Conserved Domains (2) summary
      cd00195
      Location:6 → 149
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      cd14390
      Location:163 → 200
      UBA_II_E2_UBE2K; UBA domain of vertebrate ubiquitin-conjugating enzyme E2 K (UBE2K)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      43011681..43077825 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091716.2 → XP_038947644.1  ubiquitin-conjugating enzyme E2 K isoform X1

      UniProtKB/TrEMBL
      A0A8I6A2L8, A0A8I6AV01
      Related
      ENSRNOP00000085882.1
      Conserved Domains (2) summary
      cd00195
      Location:35 → 159
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      cd14390
      Location:173 → 210
      UBA_II_E2_UBE2K; UBA domain of vertebrate ubiquitin-conjugating enzyme E2 K (UBE2K)

    2. XM_039091717.2 → XP_038947645.1  ubiquitin-conjugating enzyme E2 K isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZMB3, A0A8I6AV01, A6JDD3
      Related
      ENSRNOP00000079243.1
      Conserved Domains (2) summary
      smart00212
      Location:22 → 103
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
      cl21463
      Location:112 → 149
      UBA_like_SF; UBA domain-like superfamily

    3. XM_063272925.1 → XP_063128995.1  ubiquitin-conjugating enzyme E2 K isoform X3

      UniProtKB/TrEMBL
      A6JDD5

    4. XM_063272926.1 → XP_063128996.1  ubiquitin-conjugating enzyme E2 K isoform X3

      UniProtKB/TrEMBL
      A6JDD5

    5. XM_063272927.1 → XP_063128997.1  ubiquitin-conjugating enzyme E2 K isoform X3

      UniProtKB/TrEMBL
      A6JDD5
    Nucleotide Protein Strain
    Heading Accession and Version

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