Rps6ka4 ribosomal protein S6 kinase A4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rps6ka4provided by RGD
Official Full Name: ribosomal protein S6 kinase A4provided by RGD
Primary source: RGD:1307277
See related: Ensembl:ENSRNOG00000021117 AllianceGenome:RGD:1307277
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ccdc88b
Summary: Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including histone-serine phosphorylation; interleukin-1-mediated signaling pathway; and positive regulation of histone modification. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human RPS6KA4 (ribosomal protein S6 kinase A4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 65.9), Lung (RPKM 62.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (213451026..213461982, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (204021805..204032781, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (222087328..222098284, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BG379772 (e-PCR)
- UniSTS:245581

RH134280 (e-PCR)
- UniSTS:217562

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables histone H3S10 kinase activity	ISO Inferred from Sequence Orthology more info
enables histone H3S28 kinase activity	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in interleukin-1-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in post-translational protein modification	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ribosomal protein S6 kinase alpha-4

Names: coiled-coil domain containing 88B; ribosomal protein S6 kinase, polypeptide 4

NP_001101987.2

EC 2.7.11.1

XP_038939947.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108517.2 → NP_001101987.2 ribosomal protein S6 kinase alpha-4

Status: VALIDATED

Source sequence(s)

AW251264, BF407559, BQ194971, BU671341, CB700259, CB737401, DN932052, FM035808, FM059731

UniProtKB/TrEMBL

A6HZI4, D3ZSB7

Related

ENSRNOP00000028678.6, ENSRNOT00000028678.8

Conserved Domains (2) summary

cd05614
Location:32 → 364

STKc_MSK2_N; N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 2

cl21453
Location:404 → 714

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

213451026..213461982 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039084019.2 → XP_038939947.1 ribosomal protein S6 kinase alpha-4 isoform X1

UniProtKB/TrEMBL

A6HZI4

Conserved Domains (1) summary

cl21453
Location:1 → 301

PKc_like; Protein Kinases, catalytic domain