Uimc1 ubiquitin interaction motif containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Uimc1provided by RGD
Official Full Name: ubiquitin interaction motif containing 1provided by RGD
Primary source: RGD:1307009
See related: Ensembl:ENSRNOG00000016891 AllianceGenome:RGD:1307009
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1307009
Summary: Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity; histone binding activity; and retinoid X receptor binding activity. Predicted to be involved in several processes, including histone H2A K63-linked deubiquitination; mitotic G2 DNA damage checkpoint signaling; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in nuclear body. Predicted to be part of BRCA1-A complex. Orthologous to human UIMC1 (ubiquitin interaction motif containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 119.0), Thymus (RPKM 118.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (9528923..9597967)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (9523793..9592810)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (10061915..10130921)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables K63-linked polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables K63-linked polyubiquitin modification-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables K63-linked polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables K63-linked polyubiquitin modification-dependent protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	IEA Inferred from Electronic Annotation more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear retinoid X receptor binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-modified histone reader activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-modified histone reader activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA repair-dependent chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in DNA repair-dependent chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic G2 DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info
involved_in mitotic G2 DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic G2 DNA damage checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA repair	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA repair	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to ionizing radiation	IEA Inferred from Electronic Annotation more info
involved_in response to ionizing radiation	ISO Inferred from Sequence Orthology more info
involved_in response to ionizing radiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of BRCA1-A complex	IBA Inferred from Biological aspect of Ancestor more info
part_of BRCA1-A complex	IEA Inferred from Electronic Annotation more info
part_of BRCA1-A complex	ISO Inferred from Sequence Orthology more info
part_of BRCA1-A complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in site of double-strand break	IEA Inferred from Electronic Annotation more info
is_active_in site of double-strand break	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: BRCA1-A complex subunit RAP80

Names: receptor-associated protein 80; ubiquitin interaction motif-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013884.1 → NP_001013906.1 BRCA1-A complex subunit RAP80

See identical proteins and their annotated locations for NP_001013906.1

Status: PROVISIONAL

Source sequence(s)

BC087149

UniProtKB/Swiss-Prot

Q5PQK4

UniProtKB/TrEMBL

A0A8I6ALX5

Related

ENSRNOP00000022704.6, ENSRNOT00000022703.7

Conserved Domains (2) summary

pfam18282
Location:72 → 128

RAP80_UIM; RAP80 N-terminal ubiquitin interaction motif

cd20912
Location:272 → 330

AIR_RAP80-like; ABRAXAS Interacting Region (AIR) of Receptor-Associated Protein 80 (RAP80), and related domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

9528923..9597967

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063276146.1 → XP_063132216.1 BRCA1-A complex subunit RAP80 isoform X2

UniProtKB/Swiss-Prot

Q5PQK4

UniProtKB/TrEMBL

A0A8I6ALX5
XM_039095471.2 → XP_038951399.1 BRCA1-A complex subunit RAP80 isoform X2

UniProtKB/Swiss-Prot

Q5PQK4

UniProtKB/TrEMBL

A0A8I6ALX5

Conserved Domains (2) summary

pfam18282
Location:72 → 128

RAP80_UIM; RAP80 N-terminal ubiquitin interaction motif

cd20912
Location:272 → 330

AIR_RAP80-like; ABRAXAS Interacting Region (AIR) of Receptor-Associated Protein 80 (RAP80), and related domains
XM_063276145.1 → XP_063132215.1 BRCA1-A complex subunit RAP80 isoform X2

UniProtKB/Swiss-Prot

Q5PQK4

UniProtKB/TrEMBL

A0A8I6ALX5
XM_063276147.1 → XP_063132217.1 BRCA1-A complex subunit RAP80 isoform X4

UniProtKB/TrEMBL

A0A8I6ALX5
XM_039095470.2 → XP_038951398.1 BRCA1-A complex subunit RAP80 isoform X1

UniProtKB/TrEMBL

A0A0G2K556, A0A8I6ALX5

Related

ENSRNOP00000073299.1

Conserved Domains (2) summary

pfam18282
Location:96 → 152

RAP80_UIM; RAP80 N-terminal ubiquitin interaction motif

cd20912
Location:296 → 354

AIR_RAP80-like; ABRAXAS Interacting Region (AIR) of Receptor-Associated Protein 80 (RAP80), and related domains
XM_017600476.3 → XP_017455965.2 BRCA1-A complex subunit RAP80 isoform X3

UniProtKB/TrEMBL

A0A8I6ALX5

Conserved Domains (1) summary

pfam18282
Location:96 → 152

RAP80_UIM; RAP80 N-terminal ubiquitin interaction motif
XM_039095472.2 → XP_038951400.1 BRCA1-A complex subunit RAP80 isoform X2

UniProtKB/Swiss-Prot

Q5PQK4

UniProtKB/TrEMBL

A0A8I6ALX5

Conserved Domains (2) summary

pfam18282
Location:72 → 128

RAP80_UIM; RAP80 N-terminal ubiquitin interaction motif

cd20912
Location:272 → 330

AIR_RAP80-like; ABRAXAS Interacting Region (AIR) of Receptor-Associated Protein 80 (RAP80), and related domains