Olah oleoyl-ACP hydrolase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Olahprovided by RGD
Official Full Name: oleoyl-ACP hydrolaseprovided by RGD
Primary source: RGD:621115
See related: Ensembl:ENSRNOG00000016403 AllianceGenome:RGD:621115
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mch; Thedc1
Summary: Enables acyl-[acyl-carrier-protein] hydrolase activity. Involved in medium-chain fatty acid biosynthetic process. Located in cytosol. Orthologous to human OLAH (oleoyl-ACP hydrolase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 48.4), Lung (RPKM 5.7) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (79786441..79811692)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (74877651..74902517)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (78878673..78903919)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sex differences in the response of MCH neurons to glucose correlated well with the gonadal steroid milieu.
Title: Sex difference in the response of melanin-concentrating hormone neurons in the lateral hypothalamic area to glucose, as revealed by the expression of phosphorylated cyclic adenosine 3',5'-monophosphate response element-binding protein.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fatty acyl-[ACP] hydrolase activity	EXP Inferred from Experiment more info	PubMed
enables fatty acyl-[ACP] hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables fatty acyl-[ACP] hydrolase activity	ISO Inferred from Sequence Orthology more info
enables fatty acyl-[ACP] hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in lipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in medium-chain fatty acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in medium-chain fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info

General protein information

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Preferred Names: S-acyl fatty acid synthase thioesterase, medium chain

Names: medium-chain S-acyl fatty acid synthetase thio ester hydrolase (MCH); medium-chain S-acyl fatty acid synthetase thioester hydrolase; thioesterase II; thioesterase domain containing 1; thioesterase domain-containing protein 1

NP_073196.1

EC 3.1.2.14

XP_017456149.1

EC 3.1.2.14

XP_063132798.1

EC 3.1.2.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022705.2 → NP_073196.1 S-acyl fatty acid synthase thioesterase, medium chain

See identical proteins and their annotated locations for NP_073196.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

P08635

UniProtKB/TrEMBL

A0A8I6GAB2, A6JM21

Related

ENSRNOP00000022043.2, ENSRNOT00000022043.5

Conserved Domains (2) summary

pfam00975
Location:27 → 256

Thioesterase; Thioesterase domain

pfam12697
Location:36 → 244

Abhydrolase_6; Alpha/beta hydrolase family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

79786441..79811692

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017600660.3 → XP_017456149.1 S-acyl fatty acid synthase thioesterase, medium chain isoform X1

UniProtKB/Swiss-Prot

P08635

UniProtKB/TrEMBL

A0A8I6GAB2, A6JM21

Conserved Domains (2) summary

pfam00975
Location:27 → 256

Thioesterase; Thioesterase domain

pfam12697
Location:36 → 244

Abhydrolase_6; Alpha/beta hydrolase family
XM_063276728.1 → XP_063132798.1 S-acyl fatty acid synthase thioesterase, medium chain isoform X1

UniProtKB/Swiss-Prot

P08635

UniProtKB/TrEMBL

A0A8I6GAB2, A6JM21