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    Mzf1 myeloid zinc finger 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361508, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mzf1provided by RGD
    Official Full Name
    myeloid zinc finger 1provided by RGD
    Primary source
    RGD:1308391
    See related
    Ensembl:ENSRNOG00000027550 AllianceGenome:RGD:1308391
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zfp98
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Orthologous to human MZF1 (myeloid zinc finger 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 29.7), Adrenal (RPKM 15.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mzf1 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (82742709..82755069, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (73670522..73682885, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (65520827..65533233)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 28 Neighboring gene charged multivesicular body protein 2A Neighboring gene ubiquitin-conjugating enzyme E2M Neighboring gene vomeronasal 1 receptor 55 Neighboring gene vomeronasal 1 receptor 2, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dorsal root ganglion myeloid zinc finger protein 1 contributes to neuropathic pain after peripheral nerve trauma. Li Z, et al. Pain, 2015 Apr. PMID 25630025, Free PMC Article
    2. MZF1 in the Dorsal Root Ganglia Contributes to the Development and Maintenance of Neuropathic Pain via Regulation of TRPV1. Xing F, et al. Neural Plast, 2019. PMID 31582966, Free PMC Article
    3. Structure of the SCAN domain from the tumor suppressor protein MZF1. Peterson FC, et al. J Mol Biol, 2006 Oct 13. PMID 16950398, Free PMC Article
    4. The myeloid zinc finger gene, MZF-1, regulates the CD34 promoter in vitro. Morris JF, et al. Blood, 1995 Nov 15. PMID 7579328
    5. Sp1/Sp3 and the myeloid zinc finger gene MZF1 regulate the human N-cadherin promoter in osteoblasts. Le Mée S, et al. Exp Cell Res, 2005 Jan 1. PMID 15541732

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. that MZF1 may contribute to neuropathic pain via regulation of TRPV1 expression in dorsal root ganglions
      Title: MZF1 in the Dorsal Root Ganglia Contributes to the Development and Maintenance of Neuropathic Pain via Regulation of TRPV1.
    2. This study demonstrated that MZF1 participated in CCI-induced reductions in Kv1.2 mRNA and protein and total Kv current and the CCI-induced increase in neuronal excitability through MZF1-triggered Kv1.2
      Title: Dorsal root ganglion myeloid zinc finger protein 1 contributes to neuropathic pain after peripheral nerve trauma.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myeloid zinc finger 1
    Names
    zinc finger protein 98

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108470.1 → NP_001101940.1  myeloid zinc finger 1

      See identical proteins and their annotated locations for NP_001101940.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474090
      UniProtKB/TrEMBL
      A6KQK1, D3ZF35
      Related
      ENSRNOP00000055361.2, ENSRNOT00000058563.3
      Conserved Domains (4) summary
      smart00431
      Location:41 → 153
      SCAN; leucine rich region
      COG5048
      Location:358 → 717
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:544 → 564
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:443 → 463
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      82742709..82755069 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228116.5 → XP_006228178.1  myeloid zinc finger 1 isoform X1

      See identical proteins and their annotated locations for XP_006228178.1

      UniProtKB/TrEMBL
      A6KQK1, D3ZF35
      Conserved Domains (4) summary
      smart00431
      Location:41 → 153
      SCAN; leucine rich region
      COG5048
      Location:358 → 717
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:544 → 564
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:443 → 463
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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