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    Zbtb45 zinc finger and BTB domain containing 45 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308366, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zbtb45provided by RGD
    Official Full Name
    zinc finger and BTB domain containing 45provided by RGD
    Primary source
    RGD:1310920
    See related
    Ensembl:ENSRNOG00000027459 AllianceGenome:RGD:1310920
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zfp499; Znf499
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleoplasm. Orthologous to human ZBTB45 (zinc finger and BTB domain containing 45). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 28.9), Spleen (RPKM 27.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zbtb45 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (82707633..82712926, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (73634895..73639802, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (65563999..65568301)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 27 member 5 Neighboring gene small nuclear ribonucleoprotein F-like Neighboring gene uncharacterized LOC108348449 Neighboring gene tripartite motif-containing 28 Neighboring gene charged multivesicular body protein 2A Neighboring gene ubiquitin-conjugating enzyme E2M

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 45
    Names
    zinc finger protein 499

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107478.1 → NP_001100948.1  zinc finger and BTB domain-containing protein 45

      See identical proteins and their annotated locations for NP_001100948.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474090
      UniProtKB/TrEMBL
      A0A8I6ACB0, A6KQL8, D4A1A3
      Related
      ENSRNOP00000090668.1, ENSRNOT00000114030.1
      Conserved Domains (6) summary
      smart00225
      Location:34 → 124
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:413 → 480
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:413 → 433
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:467 → 489
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:23 → 122
      BTB; BTB/POZ domain
      pfam13465
      Location:453 → 478
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      82707633..82712926 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228115.5 → XP_006228177.1  zinc finger and BTB domain-containing protein 45 isoform X1

      See identical proteins and their annotated locations for XP_006228177.1

      UniProtKB/TrEMBL
      A0A8I6ACB0, A6KQL8, D4A1A3
      Conserved Domains (6) summary
      smart00225
      Location:34 → 124
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:413 → 480
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:413 → 433
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:467 → 489
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:23 → 122
      BTB; BTB/POZ domain
      pfam13465
      Location:453 → 478
      zf-H2C2_2; Zinc-finger double domain

    2. XM_006228114.5 → XP_006228176.1  zinc finger and BTB domain-containing protein 45 isoform X1

      See identical proteins and their annotated locations for XP_006228176.1

      UniProtKB/TrEMBL
      A0A8I6ACB0, A6KQL8, D4A1A3
      Conserved Domains (6) summary
      smart00225
      Location:34 → 124
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:413 → 480
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:413 → 433
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:467 → 489
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:23 → 122
      BTB; BTB/POZ domain
      pfam13465
      Location:453 → 478
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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