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    Zscan22 zinc finger and SCAN domain containing 22 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 102553002, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Zscan22provided by RGD
    Official Full Name
    zinc finger and SCAN domain containing 22provided by RGD
    Primary source
    RGD:7606541
    See related
    Ensembl:ENSRNOG00000031113 AllianceGenome:RGD:7606541
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    AZF4; Zfp128; Znf128
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within BMP signaling pathway and negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZSCAN22 (zinc finger and SCAN domain containing 22). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 48.8), Testes (RPKM 40.4) and 9 other tissues See more
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    Genomic context

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    See Zscan22 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (82588520..82599952)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (73516328..73527766)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (65675932..65702955, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 329 Neighboring gene zinc finger protein 110 Neighboring gene zinc finger protein 8 Neighboring gene uncharacterized LOC134482891 Neighboring gene ribosomal protein S5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of zinc finger encoding genes from the tumoral exocrine pancreatic cell line AR42J. Mesa K, et al. Cancer Lett, 1996 Jun 5. PMID 8635150
    2. Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1. Jiao K, et al. Mol Cell Biol, 2002 Nov. PMID 12370310, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and SCAN domain containing 22
    Names
    zinc finger and SCAN domain-containing protein 22
    zinc finger and SCAN domain-containing protein 22-like
    zinc finger protein 128
    zinc finger protein 4
    zinc finger protein 8-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001408804.1 → NP_001395733.1  zinc finger and SCAN domain containing 22 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      D4ADL6

    2. NM_001408805.1 → NP_001395734.1  zinc finger and SCAN domain containing 22 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      D4ADL6
      Related
      ENSRNOP00000026305.2, ENSRNOT00000026305.3

    3. NM_001408806.1 → NP_001395735.1  zinc finger and SCAN domain containing 22 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    4. NM_001408807.1 → NP_001395736.1  zinc finger and SCAN domain containing 22 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      82588520..82599952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039100798.2 → XP_038956726.1  zinc finger and SCAN domain containing 22 isoform X1

      UniProtKB/TrEMBL
      D4ADL6
      Conserved Domains (3) summary
      COG5048
      Location:272 → 478
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:327 → 347
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:44 → 128
      SCAN; SCAN domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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