Slc27a5 solute carrier family 27 member 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc27a5provided by RGD
Official Full Name: solute carrier family 27 member 5provided by RGD
Primary source: RGD:708535
See related: Ensembl:ENSRNOG00000019626 AllianceGenome:RGD:708535
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: BAL; rBAL-1
Summary: Enables cholate-CoA ligase activity. Involved in bile acid metabolic process. Located in intracellular membrane-bounded organelle. Part of protein-containing complex. Orthologous to human SLC27A5 (solute carrier family 27 member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 3115.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (82688742..82699335, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (73616556..73627149, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (65576599..65587192)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cholate-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables cholate-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables fatty acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables long-chain fatty acid-CoA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables very long-chain fatty acid-CoA ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bile acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in bile acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in bile acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bile acid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ketone body biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within long-chain fatty acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid import into cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within triglyceride mobilization	ISO Inferred from Sequence Orthology more info
involved_in very long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: long-chain fatty acid transport protein 5

Names: BA-CoA ligase; BACS; FATP-5; VLACS-related; VLACSR; bile acid-CoA ligase; bile acyl-CoA synthetase; cholate--CoA ligase; fatty acid transport protein 5; long-chain-fatty-acid--CoA ligase; solute carrier family 27 (fatty acid transporter), member 5; very long-chain acyl-CoA synthetase-related protein

NP_077057.1

EC 6.2.1.3

EC 6.2.1.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024143.2 → NP_077057.1 long-chain fatty acid transport protein 5

See identical proteins and their annotated locations for NP_077057.1

Status: PROVISIONAL

Source sequence(s)

AF242189

UniProtKB/Swiss-Prot

Q9ES38

UniProtKB/TrEMBL

A6KQM0

Related

ENSRNOP00000026574.2, ENSRNOT00000026575.5

Conserved Domains (2) summary

PRK08279
Location:101 → 690

PRK08279; long-chain-acyl-CoA synthetase; Validated

cl17068
Location:140 → 680

AFD_class_I; Adenylate forming domain, Class I superfamily