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    CREB1 cAMP responsive element binding protein 1 [ Gallus gallus (chicken) ]

    Gene ID: 395099, updated on 3-Apr-2024

    Summary

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    Symbol
    CREB1provided by CGNC
    Full Name
    cAMP responsive element binding protein 1provided by CGNC
    Primary source
    CGNC:49169
    See related
    Ensembl:ENSGALG00010025351
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See CREB1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 7 NC_052538.1 (11802140..11840037, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 7 NC_052579.1 (11722935..11760850, complement)

    Chromosome 7 - NC_052538.1Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing M3 Neighboring gene cyclin Y like 1 Neighboring gene uncharacterized LOC107053805 Neighboring gene methyltransferase like 21A Neighboring gene uncharacterized LOC121111272 Neighboring gene Kruppel like factor 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The nitric oxide-cGKII system relays death and survival signals during embryonic retinal development via AKT-induced CREB1 activation. Socodato R, et al. Cell Death Differ, 2014 Jun. PMID 24531539, Free PMC Article
    2. Breed-dependent transcriptional regulation of phosphoenolpyruvate carboxylase, cytosolic form, expression in the liver of broiler chickens. Guo F, et al. Poult Sci, 2013 Oct. PMID 24046422
    3. Prenatal auditory stimulation alters the levels of CREB mRNA, p-CREB and BDNF expression in chick hippocampus. Chaudhury S, et al. Int J Dev Neurosci, 2009 Oct. PMID 19559781
    4. NMDA-induced nitric oxide generation and CREB activation in central nervous system is dependent on eukaryotic elongation factor 2 kinase. Gladulich LFH, et al. Biochim Biophys Acta Mol Cell Res, 2020 Oct. PMID 32569665
    5. Glutamate accelerates RPE cell proliferation through ERK1/2 activation via distinct receptor-specific mechanisms. García S, et al. J Cell Biochem, 2008 May 15. PMID 18022816

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NMDA-induced nitric oxide generation and CREB activation in central nervous system is dependent on eukaryotic elongation factor 2 kinase.
      Title: NMDA-induced nitric oxide generation and CREB activation in central nervous system is dependent on eukaryotic elongation factor 2 kinase.
    2. results showed that a transcriptional regulatory circuit involving Ca2+ -dependent activation of CREB controls the Ca2+ uptake capability of mitochondria and hence regulates mitochondrial metabolism.
      Title: Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU.
    3. These data demonstrate that NO-mediated cGKII signaling may function to control the viability of neuronal cells during early retinal development via AKT/CREB1 activity.
      Title: The nitric oxide-cGKII system relays death and survival signals during embryonic retinal development via AKT-induced CREB1 activation.
    4. A fast-growing chicken breed had significantly higher hepatic mRNA expression levels of the cytosolic form of PEPCK and significantly higher hepatic mRNA and protein expression levels of cAMP response element binding protein 1.
      Title: Breed-dependent transcriptional regulation of phosphoenolpyruvate carboxylase, cytosolic form, expression in the liver of broiler chickens.
    5. Enhanced phosphorylation of CREB during development following prenatal sound stimulation may be responsible for cell survival. Increased levels of p-CREB again at PH1 may trigger synthesis of proteins necessary for synaptic plasticity.
      Title: Prenatal auditory stimulation alters the levels of CREB mRNA, p-CREB and BDNF expression in chick hippocampus.
    6. molecular mechanisms leading to glutamate-induced proliferation by determining ERK1/2 and CREB phoshporylation in chick RPE cells in primary culture and the human-derived RPE cell line ARPE-19
      Title: Glutamate accelerates RPE cell proliferation through ERK1/2 activation via distinct receptor-specific mechanisms.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cAMP response element binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ATF4-CREB1 transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclic AMP-responsive element-binding protein 1
    Names
    cAMP response element-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204450.3 → NP_989781.1  cyclic AMP-responsive element-binding protein 1

      See identical proteins and their annotated locations for NP_989781.1

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000236
      UniProtKB/TrEMBL
      A0A1L1S0L6, A0A8V1A7A2, E1BSK3, Q7SX83
      Related
      ENSGALP00010038221.1, ENSGALT00010061907.1
      Conserved Domains (2) summary
      cd14690
      Location:271 → 325
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:99 → 137
      pKID; pKID domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      11802140..11840037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046943402.1 → XP_046799358.1  cyclic AMP-responsive element-binding protein 1 isoform X2

    2. XM_015289371.4 → XP_015144857.1  cyclic AMP-responsive element-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A1L1S0L6, A0A8V1A7A2, E1BSK3, Q7SX83
      Related
      ENSGALP00010038218.1, ENSGALT00010061903.1
      Conserved Domains (2) summary
      cd14690
      Location:271 → 325
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:99 → 137
      pKID; pKID domain

    3. XM_040703245.2 → XP_040559179.1  cyclic AMP-responsive element-binding protein 1 isoform X3

      Conserved Domains (1) summary
      cd14690
      Location:77 → 131
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      11722935..11760850 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046920920.1 → XP_046776876.1  cyclic AMP-responsive element-binding protein 1 isoform X2

    2. XM_046920919.1 → XP_046776875.1  cyclic AMP-responsive element-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A1L1S0L6, E1BSK3, Q7SX83

    3. XM_046920921.1 → XP_046776877.1  cyclic AMP-responsive element-binding protein 1 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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