IL4 interleukin 4 [Gallus gallus (chicken)] - Gene

Summary

Symbol: IL4provided by CGNC
Full Name: interleukin 4provided by CGNC
Primary source: CGNC:50227
See related: Ensembl:ENSGALG00010016327
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	13	NC_052544.1 (16557068..16561874)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	13	NC_052585.1 (16568872..16573671)

Chromosome 13 - NC_052544.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results showed that the expression levels of IL-6, IL-8, TNF-alpha, and NF-kappaB which seemed to be a critical mediator in the inflammatory response tended to increase in the birds chronically treated with As2O3. However, the mRNA expression levels of IL-4, IL-12beta, and IL-1beta were decreased in the experiment.
Title: Arsenic Trioxide Attenuates NF-κB and Cytokine mRNA Levels in the Livers of Cocks.
Data indicate that high levels of ammonia (NH3) caused increase in interleukin 1 beta (IL-1beta) gene expression in the experimental period and interleukin 4 (IL-4) gene expression in the first week.
Title: Ammonia concentration and relative humidity in poultry houses affect the immune response of broilers.
These results show that alpha-cyclodextrin induces myogenic differentiation by the release of IL-4.
Title: α-Cyclodextrin enhances myoblast fusion and muscle differentiation by the release of IL-4.
The genes for IL9, IL4, CCL4 and NFKB were found to be associated to plumage condition, revealing relationships between the immune system and behaviour.
Title: Across-line SNP association study for direct and associative effects on feather damage in laying hens.
the chicken genome encodes genes for the homologs of mammalian interleukin-3 (IL-3), IL-4, IL-5, IL-13, and granulocyte-macrophage colony-stimulating factor (GM-CSF)
Title: Characterization of the first nonmammalian T2 cytokine gene cluster: the cluster contains functional single-copy genes for IL-3, IL-4, IL-13, and GM-CSF, a gene for IL-5 that appears to be a pseudogene, and a gene encoding another cytokinelike transcript, KK34.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables interleukin-4 receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: interleukin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.