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    Neos Neosin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38795, updated on 10-May-2024

    Summary

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    Official Symbol
    Neosprovided by FlyBase
    Official Full Name
    Neosinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024542
    Locus tag
    Dmel_CG8614
    See related
    AllianceGenome:FB:FBgn0024542
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA.HL05936; BcDNA:HL05936; CG8614; Dmel\CG8614; l(3)L2249
    Summary
    Predicted to enable nucleic acid binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of precatalytic spliceosome. Is expressed in organism. Orthologous to human NCOA5 (nuclear receptor coactivator 5). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Neos in Genome Data Viewer
    Location:
    65E9-65E9; 3-19 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7241628..7243139)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7234728..7236239)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Birt-Hogg-Dube Neighboring gene Ribosomal protein L18 Neighboring gene mitochondrial ribosomal protein L50 Neighboring gene meiotic P22 Neighboring gene Cell division cycle 27

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcripts immunoprecipitated with Sxl protein in primordial germ cells of Drosophila embryos. Ota R, et al. Dev Growth Differ, 2017 Dec. PMID 29124738
    2. Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. Herold N, et al. Mol Cell Biol, 2009 Jan. PMID 18981222, Free PMC Article
    3. spenito is required for sex determination in Drosophila melanogaster. Yan D, et al. Proc Natl Acad Sci U S A, 2015 Sep 15. PMID 26324914, Free PMC Article
    4. Expression-Based Cell Lineage Analysis in Drosophila Through a Course-Based Research Experience for Early Undergraduates. Olson JM, et al. G3 (Bethesda), 2019 Nov 5. PMID 31690598, Free PMC Article
    5. The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes. Spradling AC, et al. Genetics, 1999 Sep. PMID 10471706, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    neosin
    Names
    CG8614-PA
    CG8614-PB
    Neos-PA
    Neos-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7241628..7243139
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079231.4 → NP_523955.1  neosin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523955.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KLX0, Q9U9Q2, Q9VS35
      Related
      FBpp0076546
      Conserved Domains (2) summary
      TIGR01642
      Location:19 → 149
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      cl17169
      Location:20 → 78
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_001274573.1 → NP_001261502.1  neosin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261502.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KLX0, Q9U9Q2, Q9VS35
      Conserved Domains (2) summary
      TIGR01642
      Location:19 → 149
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      cl17169
      Location:20 → 78
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KLX0 Q7KLX0
    Q9U9Q2 Q9U9Q2

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