csul capsuleen [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: csulprovided by FlyBase
Official Full Name: capsuleenprovided by FlyBase
Primary source: FLYBASE:FBgn0015925
Locus tag: Dmel_CG3730
See related: AllianceGenome:FB:FBgn0015925
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ART5; CG3730; Csul; dart5; Dart5; DART5; Dmel\CG3730; dprmt5; dPRMT5; JBP1; PRMT5
Summary: Enables protein-arginine omega-N symmetric methyltransferase activity. Involved in intracellular mRNA localization; peptidyl-arginine methylation; and pole plasm assembly. Predicted to be active in cytosol and nucleus. Is expressed in embryonic/larval midgut; head mesoderm; organism; ovary; and trunk mesoderm. Orthologous to human PRMT5 (protein arginine methyltransferase 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 53A3-53A3; 2-79 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (16264652..16266959)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (12152157..12154464)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Studies indicate that protein arginine methyltransferase 5 (PRMT5) plays a role in circadian clocks regulated alternative splicing process.
Title: Alternative splicing at the right time.
results demonstrate a key role for PRMT5 in the regulation of alternative splicing
Title: A methyl transferase links the circadian clock to the regulation of alternative splicing.
Germ plasm assembly requires symmetrically dimethylated modification of Aub by dPRMT5, which, in turn, is required for binding to Tudor.
Title: Arginine methylation of Aubergine mediates Tudor binding and germ plasm localization.
in germline cells, piRNAs are quality-controlled by dPRMT5 that modifies PIWI proteins, in tight association with Tud
Title: Functional involvement of Tudor and dPRMT5 in the piRNA processing pathway in Drosophila germlines.
The Drosophila homologue of protein methyltransferase 5 (dPRMT5, csul/dart5)methylates arginine in Drosophila Piwi, Ago3 and Aub proteins in vivo. Arginine methylation of Piwi proteins is required for Ago3 and Aub stability.
Title: Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability.
Capsuleen is essential for methylation of spliceosomal Sm proteins and germ cell formation.
Title: Arginine methyltransferase Capsuleen is essential for methylation of spliceosomal Sm proteins and germ cell formation in Drosophila.
Dart5 has a role in germ-cell development.
Title: The Sm-protein methyltransferase, dart5, is essential for germ-cell specification and maintenance.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ha3298 (e-PCR)
- UniSTS:515675

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables histone arginine N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein-arginine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-arginine N-methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein-arginine omega-N symmetric methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in P granule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in P granule organization	TAS Traceable Author Statement more info	PubMed
involved_in intracellular mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-arginine methylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pole plasm assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pole plasm protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: capsuleen

Names: CG3730-PA; CG3730-PB; capsuleenn; csul-PA; csul-PB; drosophila arginine methyltransferase 5

NP_477184.1

EC 2.1.1.-

EC 2.1.1.320

NP_725552.1

EC 2.1.1.-

EC 2.1.1.320

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

16264652..16266959

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057836.4 → NP_477184.1 capsuleen, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477184.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O46117, Q8MKK9, Q9U6Y9, Q9V7L8

UniProtKB/TrEMBL

E8NH07

Related

FBpp0088810

Conserved Domains (2) summary

pfam05185
Location:163 → 589

PRMT5; PRMT5 arginine-N-methyltransferase

pfam16950
Location:165 → 442

SAMBD; SAM-binding_domain
NM_166158.2 → NP_725552.1 capsuleen, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725552.1

Status: REVIEWED

UniProtKB/TrEMBL

E8NH07

Related

FBpp0088811

Conserved Domains (2) summary

pfam05185
Location:158 → 584

PRMT5; PRMT5 arginine-N-methyltransferase

pfam16950
Location:160 → 437

SAMBD; SAM-binding_domain