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    Czib CXXC motif containing zinc binding protein [ Mus musculus (house mouse) ]

    Gene ID: 74098, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Czibprovided by MGI
    Official Full Name
    CXXC motif containing zinc binding proteinprovided by MGI
    Primary source
    MGI:MGI:1921348
    See related
    Ensembl:ENSMUSG00000028608 AllianceGenome:MGI:1921348
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610037L13Rik; 1110008H16Rik
    Summary
    Predicted to enable zinc ion binding activity. Orthologous to human CZIB (CXXC motif containing zinc binding protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 22.6), limb E14.5 (RPKM 18.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Czib in Genome Data Viewer
    Location:
    4 C7; 4 50.18 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (107746982..107755000)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (107889785..107897803)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor-related protein 8, apolipoprotein e receptor, opposite strand 2 Neighboring gene low density lipoprotein receptor-related protein 8, apolipoprotein e receptor Neighboring gene STARR-positive B cell enhancer ABC_E4643 Neighboring gene STARR-positive B cell enhancer ABC_E1649 Neighboring gene mago homolog, exon junction complex core component Neighboring gene carnitine palmitoyltransferase 2 Neighboring gene predicted gene, 40221

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    CXXC motif containing zinc binding protein
    Names
    UPF0587 protein C1orf123 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347160.1 → NP_001334089.1  CXXC motif containing zinc binding protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL611936
      Consensus CDS
      CCDS84769.1
      UniProtKB/Swiss-Prot
      A2A8E3, A2A8E5, Q8BHG2, Q8C7D6, Q9D1H2, Q9DCH5
      UniProtKB/TrEMBL
      A2A8E2
      Related
      ENSMUSP00000114234.2, ENSMUST00000135454.8
      Conserved Domains (1) summary
      pfam05907
      Location:6 → 157
      DUF866; Eukaryotic protein of unknown function (DUF866)

    2. NM_028754.2 → NP_083030.1  CXXC motif containing zinc binding protein isoform 1

      See identical proteins and their annotated locations for NP_083030.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL611936
      Consensus CDS
      CCDS18442.1
      UniProtKB/Swiss-Prot
      Q8BHG2
      Related
      ENSMUSP00000119565.2, ENSMUST00000125107.8
      Conserved Domains (1) summary
      pfam05907
      Location:42 → 193
      DUF866; Eukaryotic protein of unknown function (DUF866)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      107746982..107755000
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253839.1 → XP_030109699.1  CXXC motif containing zinc binding protein isoform X3

      UniProtKB/TrEMBL
      B7ZC72
      Related
      ENSMUSP00000102338.4, ENSMUST00000106727.10
      Conserved Domains (1) summary
      pfam05907
      Location:8 → 136
      DUF866; Eukaryotic protein of unknown function (DUF866)

    2. XM_036164493.1 → XP_036020386.1  CXXC motif containing zinc binding protein isoform X5

      Conserved Domains (1) summary
      pfam05907
      Location:3 → 108
      DUF866; Eukaryotic protein of unknown function (DUF866)

    3. XM_006503440.4 → XP_006503503.1  CXXC motif containing zinc binding protein isoform X4

      Conserved Domains (1) summary
      pfam05907
      Location:4 → 128
      DUF866; Eukaryotic protein of unknown function (DUF866)

    4. XM_006503437.4 → XP_006503500.1  CXXC motif containing zinc binding protein isoform X1

      UniProtKB/TrEMBL
      A2A8E2
      Conserved Domains (1) summary
      pfam05907
      Location:9 → 157
      DUF866; Eukaryotic protein of unknown function (DUF866)

    5. XM_006503439.3 → XP_006503502.1  CXXC motif containing zinc binding protein isoform X2

      UniProtKB/TrEMBL
      B7ZC72
      Conserved Domains (1) summary
      pfam05907
      Location:9 → 137
      DUF866; Eukaryotic protein of unknown function (DUF866)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHG2.1 GenPept UniProtKB/Swiss-Prot:Q8BHG2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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