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    Poglut3 protein O-glucosyltransferase 3 [ Mus musculus (house mouse) ]

    Gene ID: 68304, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Poglut3provided by MGI
    Official Full Name
    protein O-glucosyltransferase 3provided by MGI
    Primary source
    MGI:MGI:1923765
    See related
    Ensembl:ENSMUSG00000034487 AllianceGenome:MGI:1923765
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kdelc2; 2010004J24Rik; 4833410J10Rik
    Summary
    Predicted to enable UDP-glucosyltransferase activity and UDP-xylosyltransferase activity. Predicted to be involved in protein O-linked glycosylation via serine. Predicted to be located in endoplasmic reticulum. Predicted to be active in endomembrane system. Is expressed in liver and white fat. Orthologous to human POGLUT3 (protein O-glucosyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 6.7), bladder adult (RPKM 5.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Poglut3 in Genome Data Viewer
    Location:
    9 A5.3; 9 29.12 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (53294217..53313167)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (53383004..53401867)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene DEAD box helicase 10 Neighboring gene STARR-positive B cell enhancer ABC_E1786 Neighboring gene STARR-seq mESC enhancer starr_24140 Neighboring gene exophilin 5 Neighboring gene STARR-seq mESC enhancer starr_24141 Neighboring gene RIKEN cDNA 4930550C14 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:53213128-53213311 Neighboring gene microRNA 130c Neighboring gene ataxia telangiectasia mutated Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:53344652-53344897

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase. Takeuchi H, et al. Proc Natl Acad Sci U S A, 2011 Oct 4. PMID 21949356, Free PMC Article
    2. Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi. Fernandez-Valdivia R, et al. Development, 2011 May. PMID 21490058, Free PMC Article
    3. Identification of cathepsin K as a novel marker of adiposity in white adipose tissue. Chiellini C, et al. J Cell Physiol, 2003 May. PMID 12652657
    4. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
    5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables UDP-glucosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables UDP-xylosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein O-linked glycosylation via serine ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein O-glucosyltransferase 3
    Names
    KDEL (Lys-Asp-Glu-Leu) containing 2
    KDEL motif-containing protein 2
    protein O-xylosyltransferase POGLUT3
    NP_997610.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212445.2 → NP_997610.1  protein O-glucosyltransferase 3 precursor

      See identical proteins and their annotated locations for NP_997610.1

      Status: VALIDATED

      Source sequence(s)
      AC079869, AK019513, AK020078, AK075811, AK076412
      Consensus CDS
      CCDS23182.1
      UniProtKB/Swiss-Prot
      G5E897, Q8C6F3
      Related
      ENSMUSP00000039313.4, ENSMUST00000037853.5
      Conserved Domains (3) summary
      smart00557
      Location:24 → 128
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:22 → 126
      Filamin; Filamin/ABP280 repeat
      cl23835
      Location:147 → 481
      Glyco_transf_90; Glycosyl transferase family 90

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      53294217..53313167
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004935541.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5E897.1 GenPept UniProtKB/Swiss-Prot:G5E897

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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