Kit KIT proto-oncogene receptor tyrosine kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kitprovided by RGD
Official Full Name: KIT proto-oncogene receptor tyrosine kinaseprovided by RGD
Primary source: RGD:620568
See related: Ensembl:ENSRNOG00000002227 AllianceGenome:RGD:620568
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein tyrosine kinase activity. Involved in several processes, including gamete generation; positive regulation of gastro-intestinal system smooth muscle contraction; and protein phosphorylation. Located in acrosomal vesicle; cytoplasmic side of plasma membrane; and external side of plasma membrane. Used to study aplastic anemia and male infertility. Biomarker of acute pancreatitis and gastroschisis. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; gastrointestinal stromal tumor; germ cell cancer (multiple); piebaldism; and renal cell carcinoma. Orthologous to human KIT (KIT proto-oncogene, receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 350.8), Brain (RPKM 125.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p11

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (32901615..32978895, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (32547459..32624694, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (35072131..35149638, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Receptor tyrosine kinase C-kit promotes a destructive phenotype of FLS in osteoarthritis via intracellular EMT signaling.
Title: Receptor tyrosine kinase C-kit promotes a destructive phenotype of FLS in osteoarthritis via intracellular EMT signaling.
We found that c-kit(+) progenitor/stem cells accelerated kidney recovery by improving foot process effacement (foot process width was lower in c-kit group vs saline treated animals, P = 0.03).
Title: Kidney-derived c-kit(+) progenitor/stem cells contribute to podocyte recovery in a model of acute proteinuria.
SDF1a gradient associates with the distribution of c-Kit+ cardiac cells in the heart and promotes heart regeneration after myocardial infarction.
Title: SDF1 gradient associates with the distribution of c-Kit+ cardiac cells in the heart.
the SCF/c-KIT system is aberrantly expressed in varicocele(VC) testis, which could be involved in male infertility caused by VC.
Title: Aberrant expressions of stem cell factor/c-KIT in rat testis with varicocele.
exosomal miR-21 derived from H2O2-treated MSCs could be transported to C-kit+ cardiac stem cells to functionally inhibit PTEN expression, thereby activating PI3K/AKT signaling and leading to protection against oxidative stress-triggered cell death
Title: Bone marrow mesenchymal stem cell-derived exosomal miR-21 protects C-kit+ cardiac stem cells from oxidative injury through the PTEN/PI3K/Akt axis.
A role of KIT receptor signaling for proliferation and differentiation of rat stem Leydig cells, is reported.
Title: A role of KIT receptor signaling for proliferation and differentiation of rat stem Leydig cells in vitro.
It was concluded that the exposure of cadimium on newborn rats ovaries could inhibit follicle development. SCF/c-kit system might mediate follicle development damage caused by cadmium, which is associated with DNA hypomethylation of SCF/c-kit promoter region may be worthy of further study.
Title: Cadmium exposure in newborn rats ovary induces developmental disorders of primordial follicles and the differential expression of SCF/c-kit gene.
An in vitro model for the assessment of stem cell fate following implantation within the infarct microenvironment identifies ISL-1 expression as the strongest predictor of c-Kit(+) cardiac progenitor cells' therapeutic potential.
Title: An in vitro model for the assessment of stem cell fate following implantation within the infarct microenvironment identifies ISL-1 expression as the strongest predictor of c-Kit(+) cardiac progenitor cells' therapeutic potential.
Immunoexpressions of embryonic and nonembryonic stem cell markers (Nanog, Thy-1, c-kit) and cellular connections (connexin 43 and occludin) on testicular tissue in thyrotoxicosis rat model
Title: Immunoexpressions of embryonic and nonembryonic stem cell markers (Nanog, Thy-1, c-kit) and cellular connections (connexin 43 and occludin) on testicular tissue in thyrotoxicosis rat model.
Study demonstrated that a genetic variant in intron 1 of Kit is both necessary and sufficient to disrupt normal urogenital development in the ACI rat.
Title: Genetic etiology of renal agenesis: fine mapping of Renag1 and identification of Kit as the candidate functional gene.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Kit (e-PCR), detects polymorphism
- UniSTS:226054

Kit (e-PCR), detects polymorphism
- UniSTS:532303

D14Rat13 (e-PCR)
- UniSTS:118354

Kit (e-PCR), detects polymorphism
- UniSTS:527042

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables SH2 domain binding	ISO Inferred from Sequence Orthology more info
enables cytokine binding	ISO Inferred from Sequence Orthology more info
enables growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables stem cell factor receptor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in Fc receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Kit signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in Kit signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in detection of mechanical stimulus involved in sensory perception of sound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within developmental pigmentation	ISO Inferred from Sequence Orthology more info
involved_in digestive tract development	ISO Inferred from Sequence Orthology more info
acts_upstream_of ectopic germ cell programmed cell death	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ectopic germ cell programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in embryonic hemopoiesis	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in erythropoietin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glycosphingolipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in hematopoietic progenitor cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hematopoietic stem cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hemopoiesis	ISO Inferred from Sequence Orthology more info
involved_in immature B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in lamellipodium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lymphoid progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	ISO Inferred from Sequence Orthology more info
involved_in mast cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in mast cell degranulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mast cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in mast cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of mast cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in megakaryocyte development	ISO Inferred from Sequence Orthology more info
involved_in melanocyte adhesion	ISO Inferred from Sequence Orthology more info
involved_in melanocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in melanocyte migration	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within myeloid progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of developmental process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of reproductive process	ISO Inferred from Sequence Orthology more info
involved_in ovarian follicle development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pigmentation	ISO Inferred from Sequence Orthology more info
involved_in pigmentation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of colon smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendritic cell cytokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of long-term neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mast cell cytokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mast cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of pseudopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of pyloric antrum smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of small intestine smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in regulation of bile acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to radiation	ISO Inferred from Sequence Orthology more info
involved_in somatic stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatid development	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in tongue development	IEP Inferred from Expression Pattern more info	PubMed
involved_in visual learning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mast/stem cell growth factor receptor Kit

Names: Kit oncogene; c-kit receptor tyrosine kinase; protein kinase; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

NP_071600.1

EC 2.7.10.1

XP_006250971.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022264.2 → NP_071600.1 mast/stem cell growth factor receptor Kit precursor

See identical proteins and their annotated locations for NP_071600.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

A0A0G2JTL4, A6JCZ9, B7SCI8, Q63116

Related

ENSRNOP00000003050.1, ENSRNOT00000003050.4

Conserved Domains (6) summary

cd05860
Location:313 → 413

Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)

smart00410
Location:220 → 309

IG_like; Immunoglobulin like

pfam00047
Location:216 → 307

ig; Immunoglobulin domain

pfam07714
Location:591 → 925

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:428 → 503

Ig; Immunoglobulin domain

cl21453
Location:555 → 929

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

32901615..32978895 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006250909.5 → XP_006250971.1 mast/stem cell growth factor receptor Kit isoform X1

See identical proteins and their annotated locations for XP_006250971.1

UniProtKB/TrEMBL

A0A0G2JTL4

Conserved Domains (6) summary

cd05860
Location:313 → 413

Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)

smart00410
Location:220 → 309

IG_like; Immunoglobulin like

pfam00047
Location:216 → 307

ig; Immunoglobulin domain

pfam07714
Location:587 → 921

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:428 → 503

Ig; Immunoglobulin domain

cl21453
Location:551 → 925

PKc_like; Protein Kinases, catalytic domain