Aldoa aldolase, fructose-bisphosphate A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aldoaprovided by RGD
Official Full Name: aldolase, fructose-bisphosphate Aprovided by RGD
Primary source: RGD:2089
See related: Ensembl:ENSRNOG00000052802 AllianceGenome:RGD:2089
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Aldo1; RNALDOG5
Summary: Predicted to enable several functions, including fructose binding activity; fructose-bisphosphate aldolase activity; and identical protein binding activity. Involved in several processes, including methylglyoxal biosynthetic process; response to estrogen; and response to lipopolysaccharide. Located in heterochromatin and mitochondrion. Orthologous to human ALDOA (aldolase, fructose-bisphosphate A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 41307.8), Heart (RPKM 6179.8) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q36

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (190832820..190838021, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (181402275..181407476, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (198228387..198233988, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data identified glycolytic enzymes GAPDH and aldolase A as putative interacting proteins for cardiac ATP-sensitive potassium (K(ATP)) channels.
Title: Cardiac ATP-sensitive K+ channel associates with the glycolytic enzyme complex.
In PC12 cells, DA exposure leads to a cellular response indicative of ER stress prior to the onset of cell death, providing a potential link between DA and the unfolded protein response in the pathogenesis of Parkinson's disease.
Title: Changes in endoplasmic reticulum stress proteins and aldolase A in cells exposed to dopamine.
Data indicate the presence of a modulated interaction between fructose-1,6-bisphosphatase and aldolase B, and suggest that in kidney, aldolase B specifically participates in gluconeogenesis and with aldolase A in glycolysis.
Title: Different involvement for aldolase isoenzymes in kidney glucose metabolism: aldolase B but not aldolase A colocalizes and forms a complex with FBPase.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Arb19 (e-PCR)
- UniSTS:240128

RH47250 (e-PCR)
- UniSTS:89094

Aldoa (e-PCR), detects polymorphism
- UniSTS:506724

D1Mco16 (e-PCR)
- UniSTS:240496

D1Wox41 (e-PCR)
- UniSTS:239551

ALDOA (e-PCR)
- UniSTS:504783

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytoskeletal protein binding	ISO Inferred from Sequence Orthology more info
enables fructose binding	ISO Inferred from Sequence Orthology more info
enables fructose-bisphosphate aldolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fructose-bisphosphate aldolase activity	IEA Inferred from Electronic Annotation more info
enables fructose-bisphosphate aldolase activity	ISO Inferred from Sequence Orthology more info
enables fructose-bisphosphate aldolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ATP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in binding of sperm to zona pellucida	ISO Inferred from Sequence Orthology more info
involved_in fructose 1,6-bisphosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fructose 1,6-bisphosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fructose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in glycolytic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in methylglyoxal biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nicotine	IEP Inferred from Expression Pattern more info	PubMed
involved_in striated muscle contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in I band	IEA Inferred from Electronic Annotation more info
located_in M band	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
part_of heterochromatin	IDA Inferred from Direct Assay more info	PubMed
part_of heterochromatin	ISO Inferred from Sequence Orthology more info
located_in sperm head	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: fructose-bisphosphate aldolase A

Names: aldolase A, fructose-bisphosphate; muscle-type aldolase

NP_001170776.1

EC 4.1.2.13

NP_001258465.1

EC 4.1.2.13

NP_036627.1

EC 4.1.2.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177305.1 → NP_001170776.1 fructose-bisphosphate aldolase A

See identical proteins and their annotated locations for NP_001170776.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.

Source sequence(s)

CO383722, CO398643, M14420

UniProtKB/Swiss-Prot

P05065, Q63038

UniProtKB/TrEMBL

A0A8L2R123, A6I9E6

Conserved Domains (1) summary

pfam00274
Location:15 → 364

Glycolytic; Fructose-bisphosphate aldolase class-I
NM_001271536.1 → NP_001258465.1 fructose-bisphosphate aldolase A

See identical proteins and their annotated locations for NP_001258465.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.

Source sequence(s)

CB750468, CF975930, FQ228954, FQ229100, JAXUCZ010000001

UniProtKB/Swiss-Prot

P05065, Q63038

UniProtKB/TrEMBL

A0A8L2R123, A6I9E6

Conserved Domains (1) summary

pfam00274
Location:15 → 364

Glycolytic; Fructose-bisphosphate aldolase class-I
NM_012495.2 → NP_036627.1 fructose-bisphosphate aldolase A

See identical proteins and their annotated locations for NP_036627.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.

Source sequence(s)

BC064440, CO383722, JAXUCZ010000001

UniProtKB/Swiss-Prot

P05065, Q63038

UniProtKB/TrEMBL

A0A8L2R123, A6I9E6

Related

ENSRNOP00000068764.2, ENSRNOT00000080988.2

Conserved Domains (1) summary

pfam00274
Location:15 → 364

Glycolytic; Fructose-bisphosphate aldolase class-I