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    Uqcr11 ubiquinol-cytochrome c reductase, complex III subunit XI [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690848, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Uqcr11provided by RGD
    Official Full Name
    ubiquinol-cytochrome c reductase, complex III subunit XIprovided by RGD
    Primary source
    RGD:1590985
    See related
    AllianceGenome:RGD:1590985
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Uqcr
    Summary
    Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial respiratory chain complex III. Orthologous to human UQCR11 (ubiquinol-cytochrome c reductase, complex III subunit XI). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 2309.2), Muscle (RPKM 1584.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Uqcr11 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (9955717..9960432)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9305042..9309753)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12171146..12175838)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene transcription factor 3 Neighboring gene methyl-CpG binding domain protein 3 Neighboring gene mex-3 RNA binding family member D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Disruption of a mitochondrial RNA-binding protein gene results in decreased cytochrome b expression and a marked reduction in ubiquinol-cytochrome c reductase activity in mouse heart mitochondria. Xu F, et al. Biochem J, 2008 Nov 15. PMID 18729827
    2. Proteomic analysis of succinate dehydrogenase and ubiquinol-cytochrome c reductase (Complex II and III) isolated by immunoprecipitation from bovine and mouse heart mitochondria. Schilling B, et al. Biochim Biophys Acta, 2006 Feb. PMID 16120479
    3. Architecture of Human Mitochondrial Respiratory Megacomplex I(2)III(2)IV(2). Guo R, et al. Cell, 2017 Sep 7. PMID 28844695
    4. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426
    5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial respiratory chain complex III ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquinol-cytochrome c reductase, complex III subunit XI
    Names
    cytochrome b-c1 complex subunit 10
    ubiquinol-cytochrome c reductase, 6.4kDa subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126097.2 → NP_001119569.1  ubiquinol-cytochrome c reductase, complex III subunit XI

      See identical proteins and their annotated locations for NP_001119569.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC157815, CB783645, FM080527
      UniProtKB/TrEMBL
      A9UMV7
      Conserved Domains (1) summary
      pfam08997
      Location:2 → 52
      UCR_6-4kD; Ubiquinol-cytochrome C reductase complex, 6.4kD protein

    2. NM_001287109.1 → NP_001274038.1  ubiquinol-cytochrome c reductase, complex III subunit XI

      See identical proteins and their annotated locations for NP_001274038.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      CB783645, FM080527
      UniProtKB/TrEMBL
      A9UMV7
      Conserved Domains (1) summary
      pfam08997
      Location:2 → 52
      UCR_6-4kD; Ubiquinol-cytochrome C reductase complex, 6.4kD protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      9955717..9960432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241008.4 → XP_006241070.1  ubiquinol-cytochrome c reductase, complex III subunit XI isoform X1

      See identical proteins and their annotated locations for XP_006241070.1

      UniProtKB/TrEMBL
      A9UMV7
      Conserved Domains (1) summary
      pfam08997
      Location:2 → 52
      UCR_6-4kD; Ubiquinol-cytochrome C reductase complex, 6.4kD protein
    Nucleotide Protein Strain
    Heading Accession and Version

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