Glud1 glutamate dehydrogenase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Glud1provided by RGD
Official Full Name: glutamate dehydrogenase 1provided by RGD
Primary source: RGD:2708
See related: Ensembl:ENSRNOG00000057367 AllianceGenome:RGD:2708
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gdh1; Glud; MRG-2; Ac2-281; Gludeha
Summary: Enables enzyme binding activity and glutamate dehydrogenase (NAD+) activity. Involved in cerebellum development; long-term memory; and response to aluminum ion. Located in mitochondrion. Biomarker of brain disease (multiple) and fascioliasis. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 6; hyperinsulinism; hypoglycemia; and late onset Parkinson's disease. Orthologous to several human genes including GLUD1 (glutamate dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 2449.8), Kidney (RPKM 1287.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p15

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (9646569..9680215)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (9640312..9673961)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (10661486..10695557)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GDH promotes isoprenaline-induced cardiac hypertrophy by activating mTOR signaling via elevation of alpha-ketoglutarate level.
Title: GDH promotes isoprenaline-induced cardiac hypertrophy by activating mTOR signaling via elevation of α-ketoglutarate level.
Findings demonstrate that hippocampal synapse assembly and maintenance require a tripartite molecular complex in which the ligand Cbln2 binds with presynaptic neurexin 1beta (+S4) and postsynaptic GluD1.
Title: Postsynaptic δ1 glutamate receptor assembles and maintains hippocampal synapses via Cbln2 and neurexin.
Glutamate dehydrogenase is differentially regulated in liver and muscle of rats with transplanted Guerin's carcinoma.
Title: Effects of low-dose radiation on glutamate dehydrogenase activity in tissues of rats with transplanted Guerin's carcinoma.
We find that SIRT4 and GDH1 overexpression play antagonistic roles in regulating gliogenesis
Title: Glutamate dehydrogenase 1 and SIRT4 regulate glial development.
GDH activity is involved in activation of insulin secretion.
Title: Systemic activation of glutamate dehydrogenase increases renal ammoniagenesis: implications for the hyperinsulinism/hyperammonemia syndrome.
GDH1 facilitates regeneration of BCATm that binds to E1 decarboxylase of the branched-chain alpha-keto acid dehydrogenase enzyme complex, promotes metabolon formation, branched-chain amino acid oxidation, and cycling of nitrogen through glutamate.
Title: Branched-chain amino acid metabolon: interaction of glutamate dehydrogenase with the mitochondrial branched-chain aminotransferase (BCATm).
inhibition of glutamate dehydrogenase results in sulfite neurotoxicity
Title: A mechanism of sulfite neurotoxicity: direct inhibition of glutamate dehydrogenase.
during acidosis, the pH-responsive stabilization of glutamate dehydrogenase mRNA may be accomplished by the same mechanism that affects an increase in mitochondrial glutaminase mRNA
Title: pH-responsive stabilization of glutamate dehydrogenase mRNA in LLC-PK1-F+ cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GLUD1-1 (e-PCR)
- UniSTS:511772

RH127664 (e-PCR)
- UniSTS:210974

RH94868 (e-PCR)
- UniSTS:120114

RH94869 (e-PCR)
- UniSTS:120115

RH127502 (e-PCR)
- UniSTS:210812

D16Mco9 (e-PCR)
- UniSTS:239250

GDB:277890 (e-PCR)
- UniSTS:156370

D16Mgh3 (e-PCR)
- UniSTS:239334

D16Arb11 (e-PCR)
- UniSTS:239590

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ADP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables L-leucine binding	ISO Inferred from Sequence Orthology more info
enables NAD+ binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables glutamate dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables glutamate dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables glutamate dehydrogenase [NAD(P)+] activity	ISO Inferred from Sequence Orthology more info
enables glutamate dehydrogenase [NAD(P)+] activity	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in glutamate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in glutamate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutamate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in glutamate catabolic process	TAS Traceable Author Statement more info	PubMed
involved_in glutamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glutamine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in long-term memory	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in response to aluminum ion	IDA Inferred from Direct Assay more info	PubMed
involved_in substantia nigra development	ISO Inferred from Sequence Orthology more info	PubMed
involved_in tricarboxylic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in tricarboxylic acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutamate dehydrogenase 1, mitochondrial

Names: memory-related gene 2 protein

NP_036702.1

EC 1.4.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012570.2 → NP_036702.1 glutamate dehydrogenase 1, mitochondrial precursor

See identical proteins and their annotated locations for NP_036702.1

Status: VALIDATED

Source sequence(s)

BC081841, JAXUCZ010000016

UniProtKB/Swiss-Prot

P10860, Q66HI8, Q6LC16

UniProtKB/TrEMBL

A0A8I6AGI7, A6KFS5

Related

ENSRNOP00000075032.1, ENSRNOT00000083446.2

Conserved Domains (3) summary

cd01076
Location:263 → 548

NAD_bind_1_Glu_DH; NAD(P) binding domain of glutamate dehydrogenase, subgroup 1

COG0334
Location:104 → 546

GdhA; Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]

pfam02812
Location:113 → 240

ELFV_dehydrog_N; Glu/Leu/Phe/Val dehydrogenase, dimerization domain