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    Camkk1 calcium/calmodulin-dependent protein kinase kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60341, updated on 2-May-2024

    Summary

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    Official Symbol
    Camkk1provided by RGD
    Official Full Name
    calcium/calmodulin-dependent protein kinase kinase 1provided by RGD
    Primary source
    RGD:62023
    See related
    Ensembl:ENSRNOG00000018242 AllianceGenome:RGD:62023
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables calmodulin binding activity and calmodulin-dependent protein kinase activity. Involved in activation of protein kinase activity. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human CAMKK1 (calcium/calmodulin dependent protein kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 166.6), Lung (RPKM 59.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Camkk1 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (58135872..58159023)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (57637335..57660498)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (59585023..59608180)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 Neighboring gene purinergic receptor P2X 1 Neighboring gene nuclear cap binding subunit 3 Neighboring gene integrin subunit alpha E Neighboring gene histone H3 associated protein kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway. Yano S, et al. Nature, 1998 Dec 10. PMID 9859994
    2. Calcium/calmodulin-dependent protein kinase kinase: identification of regulatory domains. Tokumitsu H, et al. Biochemistry, 1997 Oct 21. PMID 9335539
    3. Inhibitory cross-talk by cAMP kinase on the calmodulin-dependent protein kinase cascade. Wayman GA, et al. J Biol Chem, 1997 Jun 27. PMID 9195898
    4. Distribution of Ca2+/calmodulin-dependent protein kinase kinase alpha in the rat central nervous system: an immunohistochemical study. Nakamura Y, et al. Neurosci Lett, 1996 Feb 2. PMID 8929978
    5. Evidence for the existence of Ca2+/calmodulin-dependent protein kinase IV kinase isoforms in rat brain. Okuno S, et al. J Biochem, 1996 Jun. PMID 8827455

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Oligomerization of Ca(2+)/calmodulin-dependent protein kinase kinase.
      Title: Oligomerization of Ca(2+)/calmodulin-dependent protein kinase kinase.
    2. Ghrelin inhibited pressure overload-induced cardiac hypertrophy by promoting autophagy via CaMKK/AMPK signaling pathway.
      Title: Ghrelin inhibited pressure overload-induced cardiac hypertrophy by promoting autophagy via CaMKK/AMPK signaling pathway.
    3. Site-directed mutagenesis analysis revealed that Leu(358) in CaMKKbeta/Ile(322) in CaMKKalpha confer, at least in part, a distinct recognition of AMPK but not of CaMKIalpha.
      Title: Differential AMP-activated Protein Kinase (AMPK) Recognition Mechanism of Ca2+/Calmodulin-dependent Protein Kinase Kinase Isoforms.
    4. CaMKKalpha and CaMKKbeta are capable of phosphorylating and activating CaMKIV in living cells.
      Title: Analysis of Distinct Roles of CaMKK Isoforms Using STO-609-Resistant Mutants in Living Cells.
    5. CaMKII(alpha) expression levels in hippocampus of chronic epileptic rats may be related with their impaired spatial learning and memory.
      Title: Impaired spatial learning related with decreased expression of calcium/calmodulin-dependent protein kinase IIalpha and cAMP-response element binding protein in the pentylenetetrazol-kindled rats.
    6. 14-3-3 proteins directly regulate CaMKKalpha when the enzyme is phosphorylated by protein kinase A on either Ser74 or Ser475.
      Title: 14-3-3 Proteins directly regulate Ca(2+)/calmodulin-dependent protein kinase kinase alpha through phosphorylation-dependent multisite binding.
    7. Thr196 phosphorylation of CaM-KIV by CaM-KK reduces interaction of the catalytic core with the autoinhibitory region, resulting in generation of the autonomous activity
      Title: Mechanism of the generation of autonomous activity of Ca2+/calmodulin-dependent protein kinase IV.
    8. ERK activation and neurite outgrowth in response to depolarization are mediated by CaMKK activation of CaMKI
      Title: Calcium activation of ERK mediated by calmodulin kinase I.
    9. Translocation of CaMKI-alpha into the nucleus involves a conserved sequence located within the catalytic core. Mutation of this sequence partially blocks nuclear entry of an export-impaired mutant of CaMKI-alpha.
      Title: Cytoplasmic localization of calcium/calmodulin-dependent protein kinase I-alpha depends on a nuclear export signal in its regulatory domain.
    10. Lkb1 and CaMKKalpha function as Snf1 protein kinase kinases, in a cascade that is highly conserved in mouse and yeast
      Title: Function of mammalian LKB1 and Ca2+/calmodulin-dependent protein kinase kinase alpha as Snf1-activating kinases in yeast.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin-dependent protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    calcium/calmodulin-dependent protein kinase kinase 1
    Names
    alpha CaMKK
    caM-KK 1
    caM-KK alpha
    caM-kinase IV kinase
    caM-kinase kinase 1
    caM-kinase kinase alpha
    caMKK 1
    caMKK alpha
    calcium/calmodulin-dependent protein kinase kinase 1, alpha
    calcium/calmodulin-dependent protein kinase kinase alpha
    NP_113850.1
    XP_006246861.1
    XP_006246863.1
    XP_008766088.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031662.1 → NP_113850.1  calcium/calmodulin-dependent protein kinase kinase 1

      See identical proteins and their annotated locations for NP_113850.1

      Status: PROVISIONAL

      Source sequence(s)
      AB023658
      UniProtKB/Swiss-Prot
      P97756, Q64572, Q794E3
      UniProtKB/TrEMBL
      A0A8I5YBZ4
      Related
      ENSRNOP00000076910.1, ENSRNOT00000104077.1
      Conserved Domains (2) summary
      smart00220
      Location:128 → 409
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:127 → 410
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      58135872..58159023
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767866.4 → XP_008766088.1  calcium/calmodulin-dependent protein kinase kinase 1 isoform X1

      See identical proteins and their annotated locations for XP_008766088.1

      UniProtKB/TrEMBL
      A0A8I5YBZ4, A6HGH7
      Conserved Domains (1) summary
      cd14200
      Location:127 → 410
      STKc_CaMKK1; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1

    2. XM_006246799.5 → XP_006246861.1  calcium/calmodulin-dependent protein kinase kinase 1 isoform X1

      See identical proteins and their annotated locations for XP_006246861.1

      UniProtKB/TrEMBL
      A0A8I5YBZ4, A6HGH7
      Conserved Domains (1) summary
      cd14200
      Location:127 → 410
      STKc_CaMKK1; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1

    3. XM_006246801.5 → XP_006246863.1  calcium/calmodulin-dependent protein kinase kinase 1 isoform X1

      See identical proteins and their annotated locations for XP_006246863.1

      UniProtKB/TrEMBL
      A0A8I5YBZ4, A6HGH7
      Conserved Domains (1) summary
      cd14200
      Location:127 → 410
      STKc_CaMKK1; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97756.1 GenPept UniProtKB/Swiss-Prot:P97756

    Gene LinkOut

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