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    Msmb microseminoprotein, beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29311, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Msmbprovided by RGD
    Official Full Name
    microseminoprotein, betaprovided by RGD
    Primary source
    RGD:3113
    See related
    Ensembl:ENSRNOG00000039786 AllianceGenome:RGD:3113
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PSP94
    Summary
    Predicted to be located in extracellular region. Orthologous to human MSMB (microseminoprotein beta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 1.6), Uterus (RPKM 1.3) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Msmb in Genome Data Viewer
    Location:
    16p16
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (7372803..7393406)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (7366536..7387124)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (8280275..8300853)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene diphthamide biosynthesis 3 Neighboring gene oxidoreductase NAD-binding domain containing 1 Neighboring gene transfer RNA valine (anticodon AAC) 12 Neighboring gene uncharacterized LOC134482455 Neighboring gene poly (ADP-ribose) glycohydrolase like 1 Neighboring gene nuclear receptor coactivator 4 Neighboring gene translocase of inner mitochondrial membrane 23 Neighboring gene small nucleolar RNA SNORA74

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rodent PSP94 gene expression is more specific to the dorsolateral prostate and less sensitive to androgen ablation than probasin. Imasato Y, et al. Endocrinology, 2001 May. PMID 11316782
    2. Cloning of beta-microseminoprotein of the rat: a rapidly evolving mucosal surface protein. Fernlund P, et al. Arch Biochem Biophys, 1996 Oct 1. PMID 8837741
    3. Prostate tumors downregulate microseminoprotein-beta (MSMB) in the surrounding benign prostate epithelium and this response is associated with tumor aggressiveness. Bergström SH, et al. Prostate, 2018 Mar. PMID 29250809

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aggressive prostate tumors suppress MSMB synthesis in the benign prostate and this could explain why serum levels of MSMB are decreased in prostate cancer patients.
      Title: Prostate tumors downregulate microseminoprotein-beta (MSMB) in the surrounding benign prostate epithelium and this response is associated with tumor aggressiveness.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    beta-microseminoprotein
    Names
    PSP-94
    prostate secreted seminal plasma protein
    prostate secretory protein PSP94
    prostate secretory protein of 94 amino acids

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019188.1 → NP_062061.1  beta-microseminoprotein precursor

      See identical proteins and their annotated locations for NP_062061.1

      Status: PROVISIONAL

      Source sequence(s)
      U65486
      UniProtKB/Swiss-Prot
      P97580
      UniProtKB/TrEMBL
      A0A8I6GCX0, A6KFX1
      Related
      ENSRNOP00000026772.4, ENSRNOT00000026772.6
      Conserved Domains (1) summary
      pfam05825
      Location:21 → 113
      PSP94; Beta-microseminoprotein (PSP-94)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      7372803..7393406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275265.1 → XP_063131335.1  beta-microseminoprotein isoform X1

    2. XM_063275267.1 → XP_063131337.1  beta-microseminoprotein isoform X2

    3. XM_063275268.1 → XP_063131338.1  beta-microseminoprotein isoform X3

      UniProtKB/Swiss-Prot
      P97580
      UniProtKB/TrEMBL
      A0A8I6GCX0, A6KFX1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97580.1 GenPept UniProtKB/Swiss-Prot:P97580

    Gene LinkOut

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