Slc14a1 solute carrier family 14 member 1 (Kidd blood group) [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc14a1provided by RGD
Official Full Name: solute carrier family 14 member 1 (Kidd blood group)provided by RGD
Primary source: RGD:3688
See related: Ensembl:ENSRNOG00000016753 AllianceGenome:RGD:3688
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: UT3; UT-B; UTB1; UrT2; HUT11
Summary: Enables urea transmembrane transporter activity. Involved in urea transport. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human SLC14A1 (solute carrier family 14 member 1 (Kidd blood group)). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 75.8), Spleen (RPKM 72.4) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.3

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (73840568..73883925, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (71565453..71608807, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (74461064..74504475, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Urea Transporter Protein is abnormally expressed in a rat model of hepatorenal syndrome induced by succinylated gelatin
Title: Abnormal Expression of Urea Transporter Protein in a Rat Model of Hepatorenal Syndrome Induced by Succinylated Gelatin.
Report thiourea analogs as inhibitors of UT-B mediated urea transport.
Title: Structure-activity analysis of thiourea analogs as inhibitors of UT-A and UT-B urea transporters.
UT-B expression in the choroid plexus was reduced by high salt diet.
Title: High salt-diet reduces SLC14A1 gene expression in the choroid plexus of Dahl salt sensitive rats.
Thienoquinoline PU-14 is a selective UT inhibitor and has urea-selective diuretic activity.
Title: A novel small-molecule thienoquinolin urea transporter inhibitor acts as a potential diuretic.
Changes in CLC-K1, UT-A1, UT-A3, and TonEBP play important roles in the renal response to osmotic diuresis in an attempt to minimize changes in plasma osmolality and maintain water homeostasis.
Title: Urea and NaCl regulate UT-A1 urea transporter in opposing directions via TonEBP pathway during osmotic diuresis.
expression of urea transporters in short-loop DTL and DVR coincides with the development of the ability to produce a concentrated urine.
Title: Expression of urea transporters in the developing rat kidney.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH137664 (e-PCR)
- UniSTS:219751

BE102916 (e-PCR)
- UniSTS:244405

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables urea channel activity	IEA Inferred from Electronic Annotation more info
enables urea channel activity	ISO Inferred from Sequence Orthology more info
enables urea channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables urea transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables urea transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables urea transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables water transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables water transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in establishment of localization in cell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in urea transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in urea transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in urea transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in urea transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in urea transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within urea transport	ISO Inferred from Sequence Orthology more info
involved_in water transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within water transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: urea transporter 1

Names: solute carrier family 14 (urea transporter), member 1 (Kidd blood group); urea transporter B; urea transporter, erythrocyte

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019346.3 → NP_062219.3 urea transporter 1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000018

UniProtKB/Swiss-Prot

E9PSP0, P70633, P97689

UniProtKB/TrEMBL

A0A8J8XP37, A6KMX6

Related

ENSRNOP00000022598.5, ENSRNOT00000022598.7

Conserved Domains (1) summary

pfam03253
Location:56 → 340

UT; Urea transporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

73840568..73883925 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008772170.3 → XP_008770392.1 urea transporter 1 isoform X3

See identical proteins and their annotated locations for XP_008770392.1

UniProtKB/Swiss-Prot

E9PSP0, P70633, P97689

UniProtKB/TrEMBL

A0A8J8XP37, A6KMX6

Related

ENSRNOP00000088113.1

Conserved Domains (1) summary

pfam03253
Location:56 → 340

UT; Urea transporter
XM_008772169.4 → XP_008770391.1 urea transporter 1 isoform X2

UniProtKB/Swiss-Prot

E9PSP0, P70633, P97689

UniProtKB/TrEMBL

H9KVF0, M0R8C6

Related

ENSRNOP00000065722.2

Conserved Domains (1) summary

pfam03253
Location:75 → 358

UT; Urea transporter
XM_039097052.1 → XP_038952980.1 urea transporter 1 isoform X1

UniProtKB/Swiss-Prot

E9PSP0, P70633, P97689

UniProtKB/TrEMBL

A0A8I5ZWN6

Conserved Domains (1) summary

pfam03253
Location:110 → 394

UT; Urea transporter
XM_008772168.3 → XP_008770390.1 urea transporter 1 isoform X1

UniProtKB/Swiss-Prot

E9PSP0, P70633, P97689

UniProtKB/TrEMBL

A0A8I5ZWN6

Related

ENSRNOP00000083480.1, ENSRNOT00000109500.1

Conserved Domains (1) summary

pfam03253
Location:110 → 394

UT; Urea transporter

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_138834.1: Suppressed sequence

Description

NM_138834.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.