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    Repin1 replication initiator 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 445541, updated on 2-May-2024

    Summary

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    Symbol
    Repin1provided by RGD
    Full Name
    replication initiator 1provided by RGD
    Primary source
    RGD:1549707
    See related
    Ensembl:ENSRNOG00000008239 AllianceGenome:RGD:1549707
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ap4; Ap-4
    Summary
    Predicted to enable chromatin insulator sequence binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of glucose import and regulation of fatty acid transport. Predicted to be located in cytosolic ribosome; lipid droplet; and nucleus. Predicted to be active in chromosome. Orthologous to human REPIN1 (replication initiator 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 73.8), Kidney (RPKM 59.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Repin1 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (78879910..78885143)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (77548724..77554242)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (78232454..78237498)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ATPase, H+ transporting V0 subunit e2 Neighboring gene leucine rich repeat containing 61 Neighboring gene retinoic acid receptor responder 2 Neighboring gene hypothetical LOC100363281 Neighboring gene zinc finger protein 775 Neighboring gene similar to Zinc finger and SCAN domain containing protein 2 (Zinc finger protein 29)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Gene expression profiling supports the role of Repin1 in the pathophysiology of metabolic syndrome. Bahr J, et al. Endocrine, 2011 Oct. PMID 21701954
    2. Triplet repeat in the Repin1 3'-untranslated region on rat chromosome 4 correlates with facets of the metabolic syndrome. Klöting N, et al. Diabetes Metab Res Rev, 2007 Jul. PMID 17173329
    3. Repin1 maybe involved in the regulation of cell size and glucose transport in adipocytes. Ruschke K, et al. Biochem Biophys Res Commun, 2010 Sep 17. PMID 20727851
    4. Adaptor protein complex-4 (AP-4) is expressed in the central nervous system neurons and interacts with glutamate receptor delta2. Yap CC, et al. Mol Cell Neurosci, 2003 Oct. PMID 14572453
    5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data on gene expression in epididymal/subcutaneous adipose tissue suggest that Repin1 is more highly expressed in a congenic rat model of metabolic syndrome; thus, Repin1 may affect development of facets of metabolic syndrome.
      Title: Gene expression profiling supports the role of Repin1 in the pathophysiology of metabolic syndrome.
    2. The functional unknown gene, Repin1, may be a novel candidate gene for the development of facets of the metabolic syndrome.
      Title: Triplet repeat in the Repin1 3'-untranslated region on rat chromosome 4 correlates with facets of the metabolic syndrome.
    3. It is concluded that the triplet repeat expansion in 3'-UTR of Repin1 leads to metabolic disorders as found in hHTG and WOKW rats and that Repin1 could be a novel candidate gene in the development of metabolic disorders.
      Title: Triplet repeat in the Repin1 3'-untranslated region on rat chromosome 4 correlates with facets of the metabolic syndrome.
    4. findings show that glutamate receptor delta2 interacted directly with AP-4; results suggest a potential involvement of AP-4 in the trafficking of delta2 in the brain.
      Title: Adaptor protein complex-4 (AP-4) is expressed in the central nervous system neurons and interacts with glutamate receptor delta2.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin insulator sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of fatty acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of fatty acid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    replication initiator 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005893.4 → NP_001005893.1  replication initiator 1 isoform 5

      See identical proteins and their annotated locations for NP_001005893.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q68H95
      Related
      ENSRNOP00000088288.1, ENSRNOT00000117289.1
      Conserved Domains (3) summary
      COG5048
      Location:250 → 521
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:442 → 462
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:454 → 479
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001398903.2 → NP_001385832.1  replication initiator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      Conserved Domains (2) summary
      COG5048
      Location:309 → 580
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:501 → 521
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001398904.2 → NP_001385833.1  replication initiator 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      Conserved Domains (2) summary
      COG5048
      Location:308 → 579
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:500 → 520
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001398905.2 → NP_001385834.1  replication initiator 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A0H2UHG5
      Conserved Domains (2) summary
      COG5048
      Location:306 → 577
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:498 → 518
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_001398906.2 → NP_001385835.1  replication initiator 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      78879910..78885143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236427.5 → XP_006236489.1  replication initiator 1 isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHG5
      Related
      ENSRNOP00000011032.4
      Conserved Domains (2) summary
      COG5048
      Location:306 → 577
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:498 → 518
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_063286436.1 → XP_063142506.1  replication initiator 1 isoform X2

    3. XM_006236428.5 → XP_006236490.1  replication initiator 1 isoform X3

      See identical proteins and their annotated locations for XP_006236490.1

      UniProtKB/Swiss-Prot
      Q68H95
      Conserved Domains (3) summary
      COG5048
      Location:250 → 521
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:442 → 462
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:454 → 479
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68H95.1 GenPept UniProtKB/Swiss-Prot:Q68H95

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