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    Pde1c Phosphodiesterase 1c [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34594, updated on 19-Jun-2024

    Summary

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    Official Symbol
    Pde1cprovided by FlyBase
    Official Full Name
    Phosphodiesterase 1cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0264815
    Locus tag
    Dmel_CG44007
    See related
    AllianceGenome:FB:FBgn0264815
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14940; CG14942; CG14943; CG14944; CG31757; CG31758; CG42325; CG44007; Dmel\CG44007; FBgn0264815; mdcds_1440; PDE1; PDE1c; PDE1C
    Old locus tag
    Dmel_CG14940; Dmel_CG14943; Dmel_CG14944; Dmel_CG31757; Dmel_CG31758; Dmel_CG42325
    Summary
    Enables 3',5'-cyclic-AMP phosphodiesterase activity and calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity. Involved in cAMP metabolic process; cGMP metabolic process; and male mating behavior. Located in extracellular space. Is expressed in adult head; embryonic/larval circulatory system; larval midline neurons; procrystal cell; and ventral midline of embryo. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 74. Orthologous to several human genes including PDE1C (phosphodiesterase 1C). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Pde1c in Genome Data Viewer
    Location:
    33A2-33B1; 2-45 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11814156..11928572, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11814156..11928572, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene crooked legs Neighboring gene Cyclin Y Neighboring gene long non-coding RNA:CR45013 Neighboring gene long non-coding RNA:CR45014 Neighboring gene long non-coding RNA:CR43937 Neighboring gene antisense RNA:CR43936 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene extra sexcombs Neighboring gene Seminal fluid protein 33A4 Neighboring gene Seminal fluid protein 33A2 Neighboring gene Seminal fluid protein 33A3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Maltase B1 Neighboring gene Maltase B2 Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 33a Neighboring gene Odorant receptor 33b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MicroRNA-133 Targets Phosphodiesterase 1C in Drosophila and Human Oral Cancer Cells to Regulate Epithelial-Mesenchymal Transition. Jung JE, et al. J Cancer, 2021. PMID 34335946, Free PMC Article
    2. Infertility and male mating behavior deficits associated with Pde1c in Drosophila melanogaster. Morton DB, et al. Genetics, 2010 Sep. PMID 20551439, Free PMC Article
    3. Knockdown of a Cyclic Nucleotide-Gated Ion Channel Impairs Locomotor Activity and Recovery From Hypoxia in Adult Drosophila melanogaster. Qiu S, et al. Front Physiol, 2022. PMID 35530504, Free PMC Article
    4. NMDA Receptor-mediated Ca2+ Influx in the Absence of Mg2+ Block Disrupts Rest: Activity Rhythms in Drosophila. Song Q, et al. Sleep, 2017 Dec 1. PMID 29029290
    5. Antagonistic pleiotropy and mutation accumulation contribute to age-related decline in stress response. Everman ER, et al. Evolution, 2018 Feb. PMID 29214647

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. physiological function of Pde1c in Drosophila melanogaster
      Title: Infertility and male mating behavior deficits associated with Pde1c in Drosophila melanogaster.
    2. The Drosophila genome encodes five novel PDE genes in addition to dunce. Predicted PDE sequences of Drosophila show highly conserved critical domains when compared with human PDEs.
      Title: Cyclic nucleotide phosphodiesterases in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cAMP metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in male mating behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sexual reproduction HEP PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space HDA PubMed 

    General protein information

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    Preferred Names
    phosphodiesterase 1c
    Names
    CG44007-PB
    CG44007-PC
    CG44007-PD
    CG44007-PE
    CG44007-PG
    CG44007-PH
    CG44007-PJ
    CG44007-PK
    CG44007-PL
    Pde1c-PB
    Pde1c-PC
    Pde1c-PD
    Pde1c-PE
    Pde1c-PG
    Pde1c-PH
    Pde1c-PJ
    Pde1c-PK
    Pde1c-PL
    NP_001137816.1
    NP_001137817.1
    NP_001137818.1
    NP_001137819.2
    NP_001137820.1
    NP_001245994.1
    NP_001245995.2
    NP_001260395.1
    NP_609520.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      11814156..11928572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144348.4 → NP_001137820.1  phosphodiesterase 1c, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137820.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7YZV4, Q9VKE9
      UniProtKB/TrEMBL
      Q8SXR0
      Conserved Domains (2) summary
      pfam00233
      Location:468 → 687
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:327 → 383
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    2. NM_135676.6 → NP_609520.1  phosphodiesterase 1c, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609520.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7YZV4
      Related
      FBpp0306254
      Conserved Domains (2) summary
      pfam00233
      Location:239 → 458
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:98 → 154
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    3. NM_001259065.2 → NP_001245994.1  phosphodiesterase 1c, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245994.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NF02
      Conserved Domains (2) summary
      pfam00233
      Location:586 → 805
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:445 → 501
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    4. NM_001273466.1 → NP_001260395.1  phosphodiesterase 1c, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260395.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDA0
      Conserved Domains (2) summary
      pfam00233
      Location:792 → 1011
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:651 → 707
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    5. NM_001259066.2 → NP_001245995.2  phosphodiesterase 1c, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245995.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXR0, X2BZJ7
      Conserved Domains (2) summary
      pfam00233
      Location:489 → 708
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:348 → 404
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    6. NM_001144345.3 → NP_001137817.1  phosphodiesterase 1c, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137817.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZV2
      Conserved Domains (2) summary
      pfam00233
      Location:807 → 1026
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:666 → 722
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    7. NM_001144347.3 → NP_001137819.2  phosphodiesterase 1c, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137819.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZV3
      Conserved Domains (2) summary
      pfam00233
      Location:643 → 862
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:502 → 558
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    8. NM_001144344.2 → NP_001137816.1  phosphodiesterase 1c, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137816.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7YZV4, Q9VKE9
      UniProtKB/TrEMBL
      Q8SXR0
      Conserved Domains (2) summary
      pfam00233
      Location:468 → 687
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:327 → 383
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    9. NM_001144346.3 → NP_001137818.1  phosphodiesterase 1c, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137818.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZV1
      Conserved Domains (2) summary
      pfam00233
      Location:771 → 990
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:630 → 686
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7YZV1 B7YZV1
    B7YZV2 B7YZV2
    B7YZV3 B7YZV3
    B7YZV4.1 B7YZV4
    M9NF02 M9NF02
    M9PDA0 M9PDA0
    Q8SXR0 Q8SXR0
    X2BZJ7 X2BZJ7

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