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    Nha1 Na[+]/H[+] hydrogen antiporter 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33961, updated on 19-Jun-2024

    Summary

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    Official Symbol
    Nha1provided by FlyBase
    Official Full Name
    Na[+]/H[+] hydrogen antiporter 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0031865
    Locus tag
    Dmel_CG10806
    See related
    AllianceGenome:FB:FBgn0031865
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10806; Dmel\CG10806; DmNHA1; nha1; NHA1
    Summary
    Enables chloride transmembrane transporter activity and sodium:proton antiporter activity. Involved in renal sodium ion transport. Located in brush border. Is expressed in adult Malpighian tubule; adult head; and gut section. Orthologous to several human genes including SLC9B1 (solute carrier family 9 member B1) and SLC9B2 (solute carrier family 9 member B2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Nha1 in Genome Data Viewer
    Location:
    27C1-27C1; 2-23 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6860905..6870389, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6860905..6870389, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Regulator of cyclin A1 Neighboring gene lethal (2) k09022 Neighboring gene long non-coding RNA:CR44915 Neighboring gene long non-coding RNA:CR44914

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transport proteins NHA1 and NHA2 are essential for survival, but have distinct transport modalities. Chintapalli VR, et al. Proc Natl Acad Sci U S A, 2015 Sep 15. PMID 26324901, Free PMC Article
    2. Insect capa neuropeptides impact desiccation and cold tolerance. Terhzaz S, et al. Proc Natl Acad Sci U S A, 2015 Mar 3. PMID 25730885, Free PMC Article
    3. Evolutionary origins of eukaryotic sodium/proton exchangers. Brett CL, et al. Am J Physiol Cell Physiol, 2005 Feb. PMID 15643048
    4. Identification of two partners from the bacterial Kef exchanger family for the apical plasma membrane V-ATPase of Metazoa. Day JP, et al. J Cell Sci, 2008 Aug 1. PMID 18628302
    5. Effect of spaceflight on the circadian rhythm, lifespan and gene expression of Drosophila melanogaster. Ma L, et al. PLoS One, 2015. PMID 25798821, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NHA1 and NHA2 are essential for survival, but have distinct transport modalities
      Title: Transport proteins NHA1 and NHA2 are essential for survival, but have distinct transport modalities.
    2. CG10806 is a member of the CPA2 gene family, colocalise to the same apical membrane as the plasma membrane V-ATPase and show distinct ion specificities, as expected for the Wieczorek exchanger
      Title: Identification of two partners from the bacterial Kef exchanger family for the apical plasma membrane V-ATPase of Metazoa.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chloride transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables sodium:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sodium:proton antiporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in inorganic cation transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in renal sodium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Na[+]/H[+] hydrogen antiporter 1
    Names
    CG10806-PA
    CG10806-PB
    Nha1-PA
    Nha1-PB
    serine protease

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6860905..6870389 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135236.3 → NP_609080.1  Na[+]/H[+] hydrogen antiporter 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609080.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F2FB79, Q7KTL6
      Related
      FBpp0079001
      Conserved Domains (1) summary
      pfam00999
      Location:249 → 639
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    2. NM_164717.2 → NP_723224.2  Na[+]/H[+] hydrogen antiporter 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723224.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      F2FB79, Q9VM74
      Related
      FBpp0079002
      Conserved Domains (1) summary
      pfam00999
      Location:256 → 646
      Na_H_Exchanger; Sodium/hydrogen exchanger family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KTL6 Q7KTL6
    Q95U27 Q95U27
    Q9VM74 Q9VM74

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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