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    Bcam basal cell adhesion molecule [ Mus musculus (house mouse) ]

    Gene ID: 57278, updated on 12-May-2024

    Summary

    Official Symbol
    Bcamprovided by MGI
    Official Full Name
    basal cell adhesion moleculeprovided by MGI
    Primary source
    MGI:MGI:1929940
    See related
    Ensembl:ENSMUSG00000002980 AllianceGenome:MGI:1929940
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lu; Gplu; B-CAM; 1200005K12Rik
    Summary
    Enables laminin receptor activity. Acts upstream of or within cell adhesion. Located in cell surface and plasma membrane. Is expressed in several structures, including epidermis; genitourinary system; nervous system; small intestine; and spleen. Orthologous to human BCAM (basal cell adhesion molecule (Lutheran blood group)). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in lung adult (RPKM 346.1), ovary adult (RPKM 101.5) and 11 other tissues See more
    Orthologs
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    Genomic context

    See Bcam in Genome Data Viewer
    Location:
    7 A3; 7 9.94 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19490063..19504457, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19756138..19770532, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene translocase of outer mitochondrial membrane 40 Neighboring gene predicted gene, 38955 Neighboring gene nectin cell adhesion molecule 2 Neighboring gene STARR-seq mESC enhancer starr_18217 Neighboring gene STARR-seq mESC enhancer starr_18218 Neighboring gene predicted gene, 34744 Neighboring gene STARR-seq mESC enhancer starr_18221 Neighboring gene Casitas B-lineage lymphoma c Neighboring gene STARR-positive B cell enhancer ABC_E2816 Neighboring gene STARR-seq mESC enhancer starr_18223 Neighboring gene STARR-positive B cell enhancer ABC_E1721 Neighboring gene B cell leukemia/lymphoma 3 Neighboring gene predicted gene 16174

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables laminin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables laminin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables laminin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables laminin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    basal cell adhesion molecule
    Names
    Auberger b antigen
    B-CAM cell surface glycoprotein
    Lutheran blood group
    lutheran antigen
    lutheran glycoprotein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020486.2NP_065232.1  basal cell adhesion molecule precursor

      See identical proteins and their annotated locations for NP_065232.1

      Status: VALIDATED

      Source sequence(s)
      AF109160, AF221507, AF346663, BB190832
      Consensus CDS
      CCDS39803.1
      UniProtKB/Swiss-Prot
      Q9ESS5, Q9JKB2, Q9R069
      UniProtKB/TrEMBL
      Q99K86
      Related
      ENSMUSP00000003061.8, ENSMUST00000003061.14
      Conserved Domains (5) summary
      smart00408
      Location:276334
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:32136
      IG_like; Immunoglobulin like
      pfam08205
      Location:144241
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:371438
      Ig_2; Immunoglobulin domain
      cl11960
      Location:460523
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      19490063..19504457 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)