U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Burs Bursicon [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42560, updated on 10-May-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Bursprovided by FlyBase
    Official Full Name
    Bursiconprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038901
    Locus tag
    Dmel_CG13419
    See related
    AllianceGenome:FB:FBgn0038901
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Bur alpha; burs; BURS; burs alpha; Burs alpha; burs-alpha; Burs-alpha; BursA; bursalpha; Bursalpha; Bursicon alpha; Bursicon-alpha; CG13419; Dmel\CG13419; frl; tBur
    Summary
    Enables hormone activity and protein heterodimerization activity. Contributes to neuropeptide hormone activity and neuropeptide receptor binding activity. Involved in several processes, including cuticle pigmentation; intestinal stem cell homeostasis; and ovarian follicle cell development. Located in extracellular region and terminal bouton. Part of bursicon neuropeptide hormone complex. Is expressed in several structures, including adult midgut; central nervous system; corpus cardiacum; larval thoracic segment; and neuromuscular junction. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Burs in Genome Data Viewer
    Location:
    93F9-93F9; 3-73 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21769518..21770279)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17595240..17596001)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene metabotropic GABA-B receptor subtype 2 Neighboring gene uncharacterized protein Neighboring gene RNA polymerase I subunit H

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Cellular localization of bursicon using antisera against partial peptide sequences of this insect cuticle-sclerotizing neurohormone. Honegger HW, et al. J Comp Neurol, 2002 Oct 14. PMID 12271490
    2. Eclosion gates progression of the adult ecdysis sequence of Drosophila. Peabody NC, et al. J Exp Biol, 2013 Dec 1. PMID 24031052, Free PMC Article
    3. The downregulation of the miniature gene does not replicate miniature loss-of-function phenotypes in Drosophila melanogaster wing to the full extent. Bilousov OO, et al. Tsitol Genet, 2013 Mar-Apr. PMID 23745366
    4. Command and compensation in a neuromodulatory decision network. Luan H, et al. J Neurosci, 2012 Jan 18. PMID 22262886, Free PMC Article
    5. Bursicon-α subunit modulates dLGR2 activity in the adult Drosophila melanogaster midgut independently to Bursicon-β. Scopelliti A, et al. Cell Cycle, 2016 Jun 17. PMID 27191973, Free PMC Article

    See all (115) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bursicon-alpha subunit modulates LGR2 activity in the adult Drosophila melanogaster midgut independently to Bursicon-beta.
      Title: Bursicon-α subunit modulates dLGR2 activity in the adult Drosophila melanogaster midgut independently to Bursicon-β.
    2. acts in cuticle synthesis and degradation by regulating the expression of cuticular protein and chitin metabolizing related genes
      Title: The neuropeptide bursicon acts in cuticle metabolism.
    3. results show that the functions thought to be subserved by CCAP are partially effected by bursicon, and that bursicon plays an important and heretofore undescribed role in ecdysis behavior itself.
      Title: Genetic analysis of ecdysis behavior in Drosophila reveals partially overlapping functions of two unrelated neuropeptides.
    4. Study provides evidence that bursicon release can precede the initiation of larval ecdysis, and that bursicon tans the puparium; results establish bursicon signaling as essential to insect growth and development.
      Title: The essential role of bursicon during Drosophila development.
    5. the results of this study reveal novel neuromodulatory functions for bursicon and support the hypothesis that the BSEG are essential for orchestrating both the behavioral and somatic processes underlying wing expansion.
      Title: Bursicon functions within the Drosophila CNS to modulate wing expansion behavior, hormone secretion, and cell death.
    6. the Bursicon/Rickets signaling pathway is necessary for both wing expansion and initiation of the EMT that leads to removal of the epithelial cells from the wing.
      Title: Bursicon signaling mutations separate the epithelial-mesenchymal transition from programmed cell death during Drosophila melanogaster wing maturation.
    7. identify here Drosophila bioactive bursicon as a heterodimer made of two cystine knot polypeptides
      Title: Drosophila molting neurohormone bursicon is a heterodimer and the natural agonist of the orphan receptor DLGR2.
    8. Bursicon is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2.
      Title: Bursicon, the insect cuticle-hardening hormone, is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables BMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hormone activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to neuropeptide hormone activity IC
    Inferred by Curator
    more info
    		 PubMed 
    contributes_to neuropeptide hormone activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to neuropeptide receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor ligand activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in border follicle cell delamination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chitin-based cuticle sclerotization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cuticle pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intestinal stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sequestering of BMP from receptor via BMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of bursicon neuropeptide hormone complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of bursicon neuropeptide hormone complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in terminal bouton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    bursicon
    Names
    Burs-PA
    CG13419-PA
    bursicon alpha
    bursicon alpha subunit
    bursicon alpha-subunit
    furled wing

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21769518..21770279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142726.2 → NP_650983.1  bursicon [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650983.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0APJ5, Q573B6, Q9VD83
      UniProtKB/TrEMBL
      C0MK54
      Related
      FBpp0083529
      Conserved Domains (1) summary
      cl21545
      Location:50 → 138
      GHB_like; Glycoprotein hormone beta chain homologues
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VD83.1 Q9VD83

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools