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    Ahcy Adenosylhomocysteinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32471, updated on 10-May-2024

    Summary

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    Official Symbol
    Ahcyprovided by FlyBase
    Official Full Name
    Adenosylhomocysteinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0014455
    Locus tag
    Dmel_CG11654
    See related
    AllianceGenome:FB:FBgn0014455
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ahcY; Ahcy13; CG11654; Dmel\CG11654; SAHH
    Summary
    Predicted to enable adenosylhomocysteinase activity. Involved in S-adenosylhomocysteine catabolic process. Predicted to be active in cytosol. Is expressed in several structures, including anterior endoderm; embryonic/larval lymph gland; embryonic/larval muscle system; extended germ band embryo; and gut section. Human ortholog(s) of this gene implicated in hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase. Orthologous to human AHCY (adenosylhomocysteinase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Ahcy in Genome Data Viewer
    Location:
    13C3-13C3; 1-50 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15450261..15453167)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15344294..15347200)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Cyclic nucleotide-gated ion channel-like Neighboring gene scamp Neighboring gene uncharacterized protein Neighboring gene shattered Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The S-adenosyl-L-homocysteine hydrolase of Drosophila melanogaster: identification, deduced amino acid sequence and cytological localization of the structural gene. Caggese C, et al. Mol Gen Genet, 1997 Jan 27. PMID 9037110
    2. The Transcriptional Corepressor SIN3 Directly Regulates Genes Involved in Methionine Catabolism and Affects Histone Methylation, Linking Epigenetics and Metabolism. Liu M, et al. J Biol Chem, 2017 Feb 3. PMID 28028175, Free PMC Article
    3. How tissue damage MET metabolism: Regulation of the systemic damage response. Kashio S, et al. Fly (Austin), 2017 Jan 2. PMID 27562340, Free PMC Article
    4. Disruption of Methionine Metabolism in Drosophila melanogaster Impacts Histone Methylation and Results in Loss of Viability. Liu M, et al. G3 (Bethesda), 2015 Nov 6. PMID 26546310, Free PMC Article
    5. CLOCKWORK ORANGE promotes CLOCK-CYCLE activation via the putative Drosophila ortholog of CLOCK INTERACTING PROTEIN CIRCADIAN. Rivas GBS, et al. Curr Biol, 2021 Oct 11. PMID 34331859, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables adenosylhomocysteinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenosylhomocysteinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in S-adenosylhomocysteine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in S-adenosylmethionine cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adenosylhomocysteinase
    Names
    AdoHcyase
    Ahcy-PA
    Ahcy-PB
    Ahcy-PC
    CG11654-PA
    CG11654-PB
    CG11654-PC
    S-Adenosyl-L-homocysteine hydrolase
    adenosylhomocysteinase at 13
    adenosylhomocysteinases
    NP_001259573.1
    NP_001285268.1
    NP_511164.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15450261..15453167
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298339.1 → NP_001285268.1  adenosylhomocysteinase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285268.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27580, Q8MZI1, Q9VXV5
      UniProtKB/TrEMBL
      X2JF40
      Conserved Domains (2) summary
      PRK05476
      Location:1 → 426
      PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional
      pfam05221
      Location:6 → 431
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase

    2. NM_078609.4 → NP_511164.2  adenosylhomocysteinase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511164.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27580, Q8MZI1, Q9VXV5
      UniProtKB/TrEMBL
      X2JF40
      Related
      FBpp0073847
      Conserved Domains (2) summary
      PRK05476
      Location:1 → 426
      PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional
      pfam05221
      Location:6 → 431
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase

    3. NM_001272644.1 → NP_001259573.1  adenosylhomocysteinase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259573.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHN8
      Conserved Domains (2) summary
      PRK05476
      Location:2 → 317
      PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional
      cl21454
      Location:2 → 322
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PHN8 M9PHN8
    Q27580.2 Q27580
    X2JF40 X2JF40

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