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    Dip-B Dipeptidase B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 48450, updated on 10-May-2024

    Summary

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    Official Symbol
    Dip-Bprovided by FlyBase
    Official Full Name
    Dipeptidase Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000454
    Locus tag
    Dmel_CG9285
    See related
    AllianceGenome:FB:FBgn0000454
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9285; DipB; Dmel\CG9285
    Summary
    Enables dipeptidase activity. Involved in proteolysis. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; adult heart; embryonic hindgut; excretory system; and spermatozoon. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Dip-B in Genome Data Viewer
    Location:
    87F13-87F13; 3-54 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13782288..13785676)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9608010..9611398)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45590 Neighboring gene transfer RNA:Phenylalanine-GAA 1-6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic characterization of dipeptidase activity modifiers in Drosophila melanogaster from natural populations. Hiraizumi K, et al. Biochem Genet, 1988 Dec. PMID 3149467
    2. Peptidases in Drosophila melanogaster. I. Characterization of dipeptidase and leucine aminopeptidase activities. Hall NA. Biochem Genet, 1986 Oct. PMID 3096312
    3. Genetic, ontogenetic, and tissue-specific variation of dipeptidases in Drosophila melanogaster. Laurie-Ahlberg CC. Biochem Genet, 1982 Jun. PMID 6810870
    4. Comparative studies of allozyme loci in Drosophila simulans and Drosophila melanogaster. I. Three dipeptidase loci. Ohnishi S, et al. Biochem Genet, 1981 Feb. PMID 6784720
    5. Chromosomal effects on peptidase activities in Drosophila melanogaster. Hiraizumi K, et al. Biochem Genet, 1993 Feb. PMID 8471022

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dipeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dipeptidase B
    Names
    CG9285-PA
    CG9285-PB
    CG9285-PC
    CG9285-PD
    Dip-B-PA
    Dip-B-PB
    Dip-B-PC
    Dip-B-PD
    NP_001287316.1
    NP_650318.1
    NP_731863.1
    NP_731864.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13782288..13785676
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169558.2 → NP_731864.1  dipeptidase B, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731864.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960P8, Q9VFQ9
      Related
      FBpp0082300
      Conserved Domains (1) summary
      cd00433
      Location:58 → 502
      Peptidase_M17; Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and ...

    2. NM_142061.3 → NP_650318.1  dipeptidase B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650318.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960P8, Q9VFQ9
      Related
      FBpp0082299
      Conserved Domains (1) summary
      cd00433
      Location:58 → 502
      Peptidase_M17; Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and ...

    3. NM_169557.2 → NP_731863.1  dipeptidase B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731863.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960P8, Q9VFQ9
      Related
      FBpp0082301
      Conserved Domains (1) summary
      cd00433
      Location:58 → 502
      Peptidase_M17; Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and ...

    4. NM_001300387.1 → NP_001287316.1  dipeptidase B, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287316.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960P8, Q9VFQ9
      Conserved Domains (1) summary
      cd00433
      Location:58 → 502
      Peptidase_M17; Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VFQ9 Q9VFQ9

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