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    VAChT Vesicular acetylcholine transporter [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42795, updated on 10-May-2024

    Summary

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    Official Symbol
    VAChTprovided by FlyBase
    Official Full Name
    Vesicular acetylcholine transporterprovided by FlyBase
    Primary source
    FLYBASE:FBgn0270928
    Locus tag
    Dmel_CG32848
    See related
    AllianceGenome:FB:FBgn0270928
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12345; CG32848; chn; Chn; CT41182; Dmel\CG32848; dVAChT; vacht; vAChT; Vacht; VaChT; VAcht; VACht; VACHT
    Summary
    Predicted to enable acetylcholine transmembrane transporter activity. Predicted to be involved in chemical synaptic transmission. Located in terminal bouton. Is expressed in several structures, including adult optic lobe; cholinergic neurons; indirect flight muscle cell; larval ventral nerve cord; and mushroom body calyx. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 21. Orthologous to human SLC18A3 (solute carrier family 18 member A3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See VAChT in Genome Data Viewer
    Location:
    91C1-91C3; 3-64 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18705501..18718916)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14531223..14544638)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45996 Neighboring gene uncharacterized protein Neighboring gene Choline acetyltransferase Neighboring gene long non-coding RNA:CR46265 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deficits in the vesicular acetylcholine transporter alter lifespan and behavior in adult Drosophila melanogaster. White D, et al. Neurochem Int, 2020 Jul. PMID 32315665, Free PMC Article
    2. Overexpression of the vesicular acetylcholine transporter disrupts cognitive performance and causes age-dependent locomotion decline in Drosophila. Showell SS, et al. Mol Cell Neurosci, 2020 Jun. PMID 32217162, Free PMC Article
    3. A Poly-Glutamine Region in the Drosophila VAChT Dictates Fill-Level of Cholinergic Synaptic Vesicles. Vernon SW, et al. eNeuro, 2019 Jan-Feb. PMID 30847389, Free PMC Article
    4. Data on the specificity of an antibody to Drosophila vesicular acetylcholine transporter. Boppana S, et al. Data Brief, 2017 Dec. PMID 29034290, Free PMC Article
    5. Immunolocalization of the vesicular acetylcholine transporter in larval and adult Drosophila neurons. Boppana S, et al. Neurosci Lett, 2017 Mar 16. PMID 28188850, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acetylcholine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables xenobiotic transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-1 adaptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of AP-2 adaptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in terminal bouton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in terminal bouton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vesicular acetylcholine transporter
    Names
    CG32848-PA
    Cha's neighbour
    VAChT-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18705501..18718916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057790.5 → NP_477138.1  vesicular acetylcholine transporter [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477138.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O17444, Q9VE42
      UniProtKB/TrEMBL
      D2NUG3
      Related
      FBpp0083086
      Conserved Domains (2) summary
      TIGR00880
      Location:98 → 238
      2_A_01_02; Multidrug resistance protein
      pfam07690
      Location:88 → 410
      MFS_1; Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O17444.2 O17444

    Gene LinkOut

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