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    PIG-C Phosphatidylinositol glycan anchor biosynthesis class C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38410, updated on 10-May-2024

    Summary

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    Official Symbol
    PIG-Cprovided by FlyBase
    Official Full Name
    Phosphatidylinositol glycan anchor biosynthesis class Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035435
    Locus tag
    Dmel_CG12077
    See related
    AllianceGenome:FB:FBgn0035435
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12077; Dmel\CG12077; PIGC
    Summary
    Predicted to enable phosphatidylinositol N-acetylglucosaminyltransferase activity. Involved in GPI anchor biosynthetic process and rhabdomere membrane biogenesis. Predicted to be integral component of membrane. Predicted to be part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Is expressed in organism. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human PIGC (phosphatidylinositol glycan anchor biosynthesis class C). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    See PIG-C in Genome Data Viewer
    Location:
    63D1-63D1; 3-8 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3318028..3319232, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3318028..3319232, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Drosomycin-like 4 Neighboring gene Drosomycin-like 5 Neighboring gene uncharacterized protein Neighboring gene Dolichyl-phosphate mannosyltransferase subunit 2 Neighboring gene Striatin interacting protein Neighboring gene Glutathione peroxidase homolog with thioredoxin peroxidase activity

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Strip serves as a platform for early endosome organization during axon elongation. Sakuma C, et al. Nat Commun, 2014 Oct 14. PMID 25312435, Free PMC Article
    2. Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep. Palermo J, et al. Sci Adv, 2023 Jan 6. PMID 36608130, Free PMC Article
    3. GPI biosynthesis is essential for rhodopsin sorting at the trans-Golgi network in Drosophila photoreceptors. Satoh T, et al. Development, 2013 Jan 15. PMID 23250212
    4. Steroid Signaling Establishes a Female Metabolic State and Regulates SREBP to Control Oocyte Lipid Accumulation. Sieber MH, et al. Curr Biol, 2015 Apr 20. PMID 25802149, Free PMC Article
    5. A genome-wide CRISPR screen identifies DPM1 as a modifier of DPAGT1 deficiency and ER stress. Dalton HM, et al. PLoS Genet, 2022 Sep. PMID 36166480, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GPI anchor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rhabdomere membrane biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol glycan anchor biosynthesis class C
    Names
    CG12077-PB
    CG12077-PC
    PIG-C-PB
    PIG-C-PC
    phosphatidylinositol glycan anchor biosynthesis, class C
    phosphatidylinositol glycan anchor biosynthesis, class C ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3318028..3319232 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001363927.1 → NP_001350858.1  phosphatidylinositol glycan anchor biosynthesis class C, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2U8U156, B3DND5
      Conserved Domains (1) summary
      pfam06432
      Location:12 → 270
      GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase

    2. NM_139547.2 → NP_647804.2  phosphatidylinositol glycan anchor biosynthesis class C, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647804.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DND5, Q9VZR1
      Conserved Domains (1) summary
      pfam06432
      Location:12 → 270
      GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A2U8U156 A0A2U8U156
    Q9VZR1 Q9VZR1

    Gene LinkOut

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