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    CG5103 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40012, updated on 10-May-2024

    Summary

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    Official Symbol
    CG5103provided by FlyBase
    Primary source
    FLYBASE:FBgn0036784
    Locus tag
    Dmel_CG5103
    See related
    AllianceGenome:FB:FBgn0036784
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5103
    Summary
    Predicted to enable thiamine pyrophosphate binding activity and transketolase activity. Is expressed in adult head and spermatozoon. Orthologous to several human genes including TKT (transketolase) and TKTL2 (transketolase like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG5103 in Genome Data Viewer
    Location:
    75C3-75C3; 3-45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18292125..18294262, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18285225..18287362, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45936 Neighboring gene Chemosensory protein A 75a Neighboring gene long non-coding RNA:CR43306 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. grim promotes programmed cell death of Drosophila microchaete glial cells. Wu JN, et al. Mech Dev, 2010 Sep-Dec. PMID 20558283, Free PMC Article
    2. Drosophila sickle is a novel grim-reaper cell death activator. Wing JP, et al. Curr Biol, 2002 Jan 22. PMID 11818064
    3. Coordinated expression of cell death genes regulates neuroblast apoptosis. Tan Y, et al. Development, 2011 Jun. PMID 21558369, Free PMC Article
    4. sickle, a novel Drosophila death gene in the reaper/hid/grim region, encodes an IAP-inhibitory protein. Srinivasula SM, et al. Curr Biol, 2002 Jan 22. PMID 11818063, Free PMC Article
    5. Hid arbitrates collective cell death in the Drosophila wing. Garcia-Hughes G, et al. Mech Dev, 2015 Nov. PMID 26226435, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiamine pyrophosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transketolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transketolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5103-PA
    NP_649036.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      18292125..18294262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140779.4 → NP_649036.1  uncharacterized protein Dmel_CG5103 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649036.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MZ62, Q9VVP4
      Related
      FBpp0074898
      Conserved Domains (4) summary
      cd07033
      Location:321 → 474
      TPP_PYR_DXS_TK_like; Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins
      PRK05899
      Location:12 → 621
      PRK05899; transketolase; Reviewed
      cd02012
      Location:19 → 263
      TPP_TK; Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the ...
      pfam02780
      Location:493 → 613
      Transketolase_C; Transketolase, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVP4 Q9VVP4

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