Ubqln2 ubiquilin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ubqln2provided by RGD
Official Full Name: ubiquilin 2provided by RGD
Primary source: RGD:1563566
See related: Ensembl:ENSRNOG00000003099 AllianceGenome:RGD:1563566
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1563566
Summary: Predicted to enable identical protein binding activity and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in several processes, including negative regulation of receptor-mediated endocytosis; regulation of cellular catabolic process; and ubiquitin-dependent ERAD pathway. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and amyotrophic lateral sclerosis type 15. Orthologous to human UBQLN2 (ubiquilin 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: Xq12

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (21228809..21232228, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (17853086..17856505, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (18723313..18726732, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Impaired 26S Proteasome Assembly Precedes Neuronal Loss in Mutant UBQLN2 Rats.
Title: Impaired 26S Proteasome Assembly Precedes Neuronal Loss in Mutant UBQLN2 Rats.
The results of this study suggested that selectively expressing mutant UBQLN2(P497H) in motor neurons is sufficient to trigger the development of ALS in rats
Title: Mutant UBQLN2(P497H) in motor neurons leads to ALS-like phenotypes and defective autophagy in rats.
our findings in Ubqln2 transgenic and knockout rats collectively suggest that pathogenic Ubqln2 causes neuron death mainly through a gain of unrevealed functions rather than a loss of physiological functions
Title: Pathogenic Ubqln2 gains toxic properties to induce neuron death.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of G protein-coupled receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of clathrin-dependent endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of macroautophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiquilin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108251.2 → NP_001101721.1 ubiquilin-2

See identical proteins and their annotated locations for NP_001101721.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A6KL57, D4AA63

Related

ENSRNOP00000026214.5, ENSRNOT00000026214.7

Conserved Domains (4) summary

smart00727
Location:393 → 440

STI1; Heat shock chaperonin-binding motif

cd01808
Location:33 → 103

hPLIC_N; Ubiquitin-like domain of hPLIC-1 and hPLIC2

smart00213
Location:33 → 103

UBQ; Ubiquitin homologues

cd14399
Location:595 → 634

UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins