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    Fmnl1 formin-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287746, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Fmnl1provided by RGD
    Official Full Name
    formin-like 1provided by RGD
    Primary source
    RGD:1311042
    See related
    Ensembl:ENSRNOG00000003207 AllianceGenome:RGD:1311042
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including GTPase activating protein binding activity; profilin binding activity; and small GTPase binding activity. Predicted to be involved in several processes, including actin filament severing; cortical actin cytoskeleton organization; and regulation of cell shape. Predicted to act upstream of or within substrate-dependent cell migration. Predicted to be located in phagocytic vesicle and plasma membrane. Predicted to be active in cytosol. Orthologous to human FMNL1 (formin like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 168.6), Thymus (RPKM 123.2) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fmnl1 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (88615290..88643411)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (88115876..88143342)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (91253757..91281422)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene HEXIM P-TEFb complex subunit 1 Neighboring gene HEXIM P-TEFb complex subunit 2 Neighboring gene EF-hand calcium binding domain 15 Neighboring gene spermatogenesis associated 32 Neighboring gene uncharacterized LOC120095296 Neighboring gene mitogen-activated protein kinase kinase kinase 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages. Yayoshi-Yamamoto S, et al. Mol Cell Biol, 2000 Sep. PMID 10958683, Free PMC Article
    2. Bi-modal regulation of a formin by srGAP2. Mason FM, et al. J Biol Chem, 2011 Feb 25. PMID 21148482, Free PMC Article
    3. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. Bai SW, et al. BMC Biol, 2011 Aug 11. PMID 21834987, Free PMC Article
    4. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Buschow SI, et al. Immunol Cell Biol, 2010 Nov-Dec. PMID 20458337
    5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activating protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables profilin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament severing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cortical actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cortical actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within substrate-dependent cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    formin-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105846.1 → NP_001099316.1  formin-like protein 1

      See identical proteins and their annotated locations for NP_001099316.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A6HJQ3, A6HJQ4, D3ZAZ1
      Related
      ENSRNOP00000062888.1, ENSRNOT00000065373.3
      Conserved Domains (3) summary
      pfam02181
      Location:572 → 937
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:233 → 406
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:28 → 154
      Drf_GBD; Diaphanous GTPase-binding Domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      88615290..88643411
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247499.5 → XP_006247561.1  formin-like protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZYX6
      Related
      ENSRNOP00000083255.1
      Conserved Domains (3) summary
      pfam02181
      Location:635 → 1000
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:289 → 469
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:28 → 286
      Drf_GBD; Diaphanous GTPase-binding Domain

    2. XM_006247498.5 → XP_006247560.1  formin-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYU6, A6HJQ3
      Related
      ENSRNOP00000070794.1
      Conserved Domains (3) summary
      pfam02181
      Location:635 → 1000
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:289 → 469
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:28 → 286
      Drf_GBD; Diaphanous GTPase-binding Domain

    3. XM_063268750.1 → XP_063124820.1  formin-like protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZYX6, A0A8I6A0N3

    4. XM_006247500.5 → XP_006247562.1  formin-like protein 1 isoform X3

      UniProtKB/TrEMBL
      A6HJQ3
      Conserved Domains (3) summary
      pfam02181
      Location:629 → 994
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:283 → 463
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:28 → 280
      Drf_GBD; Diaphanous GTPase-binding Domain

    5. XM_008768266.4 → XP_008766488.1  formin-like protein 1 isoform X7

      UniProtKB/TrEMBL
      A6HJQ3
      Conserved Domains (3) summary
      pfam02181
      Location:587 → 952
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:241 → 421
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:28 → 238
      Drf_GBD; Diaphanous GTPase-binding Domain

    6. XM_006247502.5 → XP_006247564.1  formin-like protein 1 isoform X4

      UniProtKB/TrEMBL
      A6HJQ3
      Conserved Domains (3) summary
      pfam02181
      Location:625 → 990
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:279 → 459
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:28 → 276
      Drf_GBD; Diaphanous GTPase-binding Domain

    7. XM_063268751.1 → XP_063124821.1  formin-like protein 1 isoform X6

      UniProtKB/TrEMBL
      A6HJQ3

    8. XM_008768267.4 → XP_008766489.1  formin-like protein 1 isoform X8

      UniProtKB/TrEMBL
      A6HJQ3
      Conserved Domains (3) summary
      pfam02181
      Location:577 → 942
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:231 → 411
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:28 → 228
      Drf_GBD; Diaphanous GTPase-binding Domain
    Nucleotide Protein Strain
    Heading Accession and Version

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