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    Foxj2 forkhead box J2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 502886, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Foxj2provided by RGD
    Official Full Name
    forkhead box J2provided by RGD
    Primary source
    RGD:1565101
    See related
    Ensembl:ENSRNOG00000009000 AllianceGenome:RGD:1565101
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565101
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in several processes, including male gamete generation; negative regulation of blood vessel endothelial cell differentiation; and positive regulation of vascular associated smooth muscle cell proliferation. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be active in nucleus. Orthologous to human FOXJ2 (forkhead box J2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 89.6), Lung (RPKM 66.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Foxj2 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (157718990..157745468)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (156047043..156073540)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (155653446..155679815)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene Nanog homeobox Neighboring gene solute carrier family 2 member 3 Neighboring gene complement C3a receptor 1 Neighboring gene ribosomal protein L31, pseudogene 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. FOXJ2 expression in rat spinal cord after injury and its role in inflammation. Chen X, et al. J Mol Neurosci, 2012 May. PMID 22246994
    2. FHX.L and FHX.S, two isoforms of the human fork-head factor FHX (FOXJ2) with differential activity. Pérez-Sánchez C, et al. J Mol Biol, 2000 Aug 25. PMID 10966786
    3. FHX, a novel fork head factor with a dual DNA binding specificity. Pérez-Sánchez C, et al. J Biol Chem, 2000 Apr 28. PMID 10777590
    4. MicroRNA-34a targets Forkhead box j2 to modulate differentiation of endothelial progenitor cells in response to shear stress. Cheng BB, et al. J Mol Cell Cardiol, 2014 Sep. PMID 24792364
    5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Li X, et al. Mol Syst Biol, 2015 Jan 21. PMID 25609649, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FOXJ2 may be involved in the pathophysiology of spinal cord injuries.
      Title: FOXJ2 expression in rat spinal cord after injury and its role in inflammation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in male meiosis I ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of blood vessel endothelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    forkhead box protein J2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109352.2 → NP_001102822.1  forkhead box protein J2

      See identical proteins and their annotated locations for NP_001102822.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6ILG0, D3Z992
      Related
      ENSRNOP00000062121.1, ENSRNOT00000065419.3
      Conserved Domains (1) summary
      pfam00250
      Location:66 → 143
      Forkhead; Forkhead domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      157718990..157745468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108257.2 → XP_038964185.1  forkhead box protein J2 isoform X2

      Conserved Domains (2) summary
      COG5025
      Location:33 → 153
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      cl00061
      Location:105 → 161
      FH_FOX; Forkhead (FH) domain found in Forkhead box (FOX) family of transcription factors and similar proteins

    2. XM_006237311.5 → XP_006237373.1  forkhead box protein J2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JW18
      Related
      ENSRNOP00000069705.1
      Conserved Domains (1) summary
      pfam00250
      Location:106 → 183
      Forkhead; Forkhead domain
    Nucleotide Protein Strain
    Heading Accession and Version

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