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    Trim14 tripartite motif-containing 14 [ Mus musculus (house mouse) ]

    Gene ID: 74735, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Trim14provided by MGI
    Official Full Name
    tripartite motif-containing 14provided by MGI
    Primary source
    MGI:MGI:1921985
    See related
    Ensembl:ENSMUSG00000039853 AllianceGenome:MGI:1921985
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    pub; 5830400N10Rik
    Summary
    Predicted to enable several functions, including protein homodimerization activity; transcription coactivator activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of viral transcription; positive regulation of I-kappaB kinase/NF-kappaB signaling; and positive regulation of NF-kappaB transcription factor activity. Predicted to act upstream of or within immune system process. Predicted to be located in cytoplasmic vesicle and mitochondrial outer membrane. Predicted to be active in cytosol and nucleoplasm. Is expressed in several structures, including central nervous system and genitourinary system. Orthologous to human TRIM14 (tripartite motif containing 14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in spleen adult (RPKM 8.5), small intestine adult (RPKM 7.5) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trim14 in Genome Data Viewer
    Location:
    4 B1; 4 24.84 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (46505072..46536148, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (46505072..46536150, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene acidic nuclear phosphoprotein 32 family member B Neighboring gene STARR-positive B cell enhancer ABC_E9585 Neighboring gene STARR-positive B cell enhancer ABC_E3487 Neighboring gene predicted gene, 22247 Neighboring gene N-acetylneuraminic acid synthase (sialic acid synthase) Neighboring gene STARR-positive B cell enhancer ABC_E3488 Neighboring gene predicted gene, 54223 Neighboring gene predicted gene, 16731 Neighboring gene coronin, actin binding protein 2A Neighboring gene STARR-positive B cell enhancer ABC_E4623 Neighboring gene STARR-positive B cell enhancer ABC_E3489 Neighboring gene STARR-positive B cell enhancer ABC_E3490 Neighboring gene predicted gene, 54221 Neighboring gene STARR-positive B cell enhancer ABC_E6173 Neighboring gene predicted gene, 54222 Neighboring gene STARR-positive B cell enhancer ABC_E2111 Neighboring gene TBC1 domain family, member 2 Neighboring gene predicted gene, 31850

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TRIM14 Is a Key Regulator of the Type I IFN Response during Mycobacterium tuberculosis Infection. Hoffpauir CT, et al. J Immunol, 2020 Jul 1. PMID 32404352, Free PMC Article
    2. TRIM14 Promotes Noncanonical NF-κB Activation by Modulating p100/p52 Stability via Selective Autophagy. Chen M, et al. Adv Sci (Weinh), 2020 Jan. PMID 31921549, Free PMC Article
    3. Trim14 overexpression causes the same transcriptional changes in mouse embryonic stem cells and human HEK293 cells. Nenasheva VV, et al. In Vitro Cell Dev Biol Anim, 2014 Feb. PMID 24092016
    4. Different effects of enhanced and reduced expression of pub gene on the formation of embryoid bodies by cultured embryonic mouse stem cell. Novosadova EV, et al. Bull Exp Biol Med, 2005 Jul. PMID 16254642
    5. Pub, a novel PU.1 binding protein, regulates the transcriptional activity of PU.1. Hirose S, et al. Biochem Biophys Res Commun, 2003 Nov 14. PMID 14592421

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An Antiviral Role for TRIM14 in Ebola Virus Infection.
      Title: An Antiviral Role for TRIM14 in Ebola Virus Infection.
    2. Tripartite motif-containing 14 may aggravate cardiac hypertrophy via the AKT signalling pathway in neonatal rat cardiomyocytes and transgenic mice.
      Title: Tripartite motif‑containing 14 may aggravate cardiac hypertrophy via the AKT signalling pathway in neonatal rat cardiomyocytes and transgenic mice.
    3. Trim14 promotes osteoclastogenesis and noncanonical NF-kappaB activation by targeting p100/p52 in chronic periodontitis.
      Title: Trim14 promotes osteoclastogenesis and noncanonical NF-κB activation by targeting p100/p52 in chronic periodontitis.
    4. TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation.
      Title: TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation.
    5. TRIM14 Is a Key Regulator of the Type I IFN Response during Mycobacterium tuberculosis Infection.
      Title: TRIM14 Is a Key Regulator of the Type I IFN Response during Mycobacterium tuberculosis Infection.
    6. study identifies new gene-type zinc finger protein 125 (RNF125) as a negative regulator of TRIM14 in the innate antiviral immune response
      Title: The Ubiquitin Ligase RNF125 Targets Innate Immune Adaptor Protein TRIM14 for Ubiquitination and Degradation.
    7. TRIM14 inhibits cGAS degradation mediated by selective autophagy receptor p62 to promote innate immune responses.
      Title: TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses.
    8. These results demonstrate the presence of the similar mechanism of trim14 gene action in different types of mammalian cells.
      Title: Trim14 overexpression causes the same transcriptional changes in mouse embryonic stem cells and human HEK293 cells.
    9. Pub gene participates in early stages of differentiation of embryonic stem cells leading to the formation of embryoid bodies.
      Title: Different effects of enhanced and reduced expression of pub gene on the formation of embryoid bodies by cultured embryonic mouse stem cell.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of NF-kappaB transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tripartite motif-containing protein 14
    Names
    PU.1 binding protein Pub

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029077.4 → NP_083353.1  tripartite motif-containing protein 14

      See identical proteins and their annotated locations for NP_083353.1

      Status: VALIDATED

      Source sequence(s)
      AB117644, AK133220, AV326753
      Consensus CDS
      CCDS18153.1
      UniProtKB/Swiss-Prot
      B1AVH3, Q6A0C3, Q762I6, Q8BVW3, Q9D3G8
      UniProtKB/TrEMBL
      Q14AR3, Q3V0E0
      Related
      ENSMUSP00000038719.7, ENSMUST00000046897.13
      Conserved Domains (2) summary
      pfam00643
      Location:20 → 56
      zf-B_box; B-box zinc finger
      cd13738
      Location:267 → 439
      SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      46505072..46536148 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164508.1 → XP_036020401.1  tripartite motif-containing protein 14 isoform X1

      UniProtKB/TrEMBL
      Q3TA17
      Conserved Domains (1) summary
      cd13738
      Location:112 → 284
      SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)

    2. XM_017320421.3 → XP_017175910.1  tripartite motif-containing protein 14 isoform X2

      UniProtKB/TrEMBL
      Q3UF89
      Conserved Domains (1) summary
      cd19768
      Location:20 → 63
      Bbox2_TRIM14; B-box-type 2 zinc finger found in tripartite motif-containing protein 14 (TRIM14) and similar proteins

    3. XM_017320420.3 → XP_017175909.1  tripartite motif-containing protein 14 isoform X2

      UniProtKB/TrEMBL
      Q3UF89
      Conserved Domains (1) summary
      cd19768
      Location:20 → 63
      Bbox2_TRIM14; B-box-type 2 zinc finger found in tripartite motif-containing protein 14 (TRIM14) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BVW3.2 GenPept UniProtKB/Swiss-Prot:Q8BVW3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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