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    MAPKKK5 mitogen-activated protein kinase kinase kinase 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836819, updated on 4-Jan-2024

    Summary

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    Gene symbol
    MAPKKK5
    Gene description
    mitogen-activated protein kinase kinase kinase 5
    Primary source
    Araport:AT5G66850
    Locus tag
    AT5G66850
    See related
    TAIR:AT5G66850
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    mitogen-activated protein kinase kinase kinase 5; MUD21.11; MUD21_11
    Summary
    member of MEKK subfamily
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    Genomic context

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    See MAPKKK5 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    11
    Sequence:
    Chromosome: 5; NC_003076.8 (26695568..26699426, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene F-box protein (DUF295) Neighboring gene SAP domain-containing protein Neighboring gene Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain-containing protein Neighboring gene ASYMMETRIC LEAVES 2-like 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. BRASSINOSTEROID-SIGNALING KINASE1 Phosphorylates MAPKKK5 to Regulate Immunity in Arabidopsis. Yan H, et al. Plant Physiol, 2018 Apr. PMID 29440595, Free PMC Article
    2. Receptor-Like Cytoplasmic Kinases Directly Link Diverse Pattern Recognition Receptors to the Activation of Mitogen-Activated Protein Kinase Cascades in Arabidopsis. Bi G, et al. Plant Cell, 2018 Jul. PMID 29871986, Free PMC Article
    3. The Arabidopsis CERK1-associated kinase PBL27 connects chitin perception to MAPK activation. Yamada K, et al. EMBO J, 2016 Nov 15. PMID 27679653, Free PMC Article
    4. Autophosphorylation profiling of Arabidopsis protein kinases using the cell-free system. Nemoto K, et al. Phytochemistry, 2011 Jul. PMID 21477822
    5. Mapping the signaling network of BIN2 kinase using TurboID-mediated biotin labeling and phosphoproteomics. Kim TW, et al. Plant Cell, 2023 Mar 15. PMID 36660928, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MITOGEN-ACTIVATED PROTEIN KINASE3 enhances disease resistance of edr1 mutants by phosphorylating MAPKKK5.
      Title: MITOGEN-ACTIVATED PROTEIN KINASE3 enhances disease resistance of edr1 mutants by phosphorylating MAPKKK5.
    2. Results indicate that brassinosteroid-signaling kinase 1 (BSK1) regulates plant immunity by phosphorylating MAPK Kinase Kinase 5 (MAPKKK5).
      Title: BRASSINOSTEROID-SIGNALING KINASE1 Phosphorylates MAPKKK5 to Regulate Immunity in Arabidopsis.
    3. PBL27 interacts with both CERK1 and the MAPK kinase kinase MAPKKK5 at the plasma membrane and knockout of MAPKKK5 compromise chitin-induced MAPK kinase activation and disease resistance to Alternaria brassicicola.
      Title: The Arabidopsis CERK1-associated kinase PBL27 connects chitin perception to MAPK activation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001345806.1
    NM_126084.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables MAP kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity HDA PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within pattern recognition receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within protein autophosphorylation HDA PubMed 
    involved_in regulation of defense response by callose deposition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of defense response to bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of defense response to fungus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase 5
    NP_569040.1
    • mitogen-activated protein kinase kinase kinase 5 (MAPKKK5); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: plasma membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT1G63700.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      26695568..26699426 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_126084.3 → NP_569040.1  mitogen-activated protein kinase kinase kinase 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_569040.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23721, Q0WLS6, Q93ZH4, Q9C5H5, Q9FKZ5
      UniProtKB/TrEMBL
      A0A178UFH6, A0A5S9YHX8
      Conserved Domains (1) summary
      cl21453
      Location:346 → 607
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001345806.1 → NP_001330515.1  mitogen-activated protein kinase kinase kinase 5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UEB7, A0A1P8BB20
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C5H5.1

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