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    PAPS1 poly(A) polymerase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838378, updated on 15-Oct-2023

    Summary

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    Gene symbol
    PAPS1
    Gene description
    poly(A) polymerase 1
    Primary source
    Araport:AT1G17980
    Locus tag
    AT1G17980
    See related
    TAIR:AT1G17980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F2H15.20; F2H15_20; poly(A) polymerase 1
    Summary
    Encodes a poly(A) polymerase. Located in the nucleus. It limits founder-cell recruitment to organ primordia and suppresses the salicylic acid-independent immune response downstream of EDS1/PAD4.
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    Genomic context

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    See PAPS1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    11
    Sequence:
    Chromosome: 1; NC_003070.9 (6187465..6191708, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene myb domain protein 52 Neighboring gene Threonyl-tRNA synthetase Neighboring gene RING/U-box superfamily protein Neighboring gene FMN-linked oxidoreductases superfamily protein Neighboring gene Major facilitator superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Poly(A) polymerase 1 contributes to competence acquisition of pollen tubes growing through the style in Arabidopsis thaliana. Ramming A, et al. Plant J, 2023 May. PMID 36811355
    2. Genome-Wide Analysis of PAPS1-Dependent Polyadenylation Identifies Novel Roles for Functionally Specialized Poly(A) Polymerases in Arabidopsis thaliana. Kappel C, et al. PLoS Genet, 2015 Aug. PMID 26305463, Free PMC Article
    3. Arabidopsis poly(A) polymerase PAPS1 limits founder-cell recruitment to organ primordia and suppresses the salicylic acid-independent immune response downstream of EDS1/PAD4. Trost G, et al. Plant J, 2014 Mar. PMID 24372773
    4. Target specificity among canonical nuclear poly(A) polymerases in plants modulates organ growth and pathogen response. Vi SL, et al. Proc Natl Acad Sci U S A, 2013 Aug 20. PMID 23918356, Free PMC Article
    5. Characterization of genes encoding poly(A) polymerases in plants: evidence for duplication and functional specialization. Meeks LR, et al. PLoS One, 2009 Nov 26. PMID 19956626, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Poly(A) polymerase 1 contributes to competence acquisition of pollen tubes growing through the style in Arabidopsis thaliana.
      Title: Poly(A) polymerase 1 contributes to competence acquisition of pollen tubes growing through the style in Arabidopsis thaliana.
    2. two novel functions of PAPS1 in ribosome biogenesis and redox homoeostasis.
      Title: Genome-Wide Analysis of PAPS1-Dependent Polyadenylation Identifies Novel Roles for Functionally Specialized Poly(A) Polymerases in Arabidopsis thaliana.
    3. role in the connection between organ identity and growth patterns
      Title: Arabidopsis poly(A) polymerase PAPS1 limits founder-cell recruitment to organ primordia and suppresses the salicylic acid-independent immune response downstream of EDS1/PAD4.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_101661.5
    NM_202126.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within petal formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    poly(A) polymerase 1
    NP_173240.2
    • poly(A) polymerase 1 (PAPS1); CONTAINS InterPro DOMAIN/s: Poly(A) polymerase (InterPro:IPR014492), Poly(A) polymerase, central domain (InterPro:IPR007012), Nucleotidyltransferase, class I, C-terminal-like (InterPro:IPR011068), Nucleotidyl transferase domain (InterPro:IPR002934), Poly(A) polymerase, RNA-binding domain (InterPro:IPR007010); BEST Arabidopsis thaliana protein match is: nuclear poly(a) polymerase (TAIR:AT4G32850.9); Has 815 Blast hits to 805 proteins in 221 species: Archae - 0; Bacteria - 17; Metazoa - 265; Fungi - 212; Plants - 181; Viruses - 0; Other Eukaryotes - 140 (source: NCBI BLink).
    NP_973855.1
    • poly(A) polymerase 1 (PAPS1); CONTAINS InterPro DOMAIN/s: Poly(A) polymerase (InterPro:IPR014492), Poly(A) polymerase, central domain (InterPro:IPR007012), Nucleotidyltransferase, class I, C-terminal-like (InterPro:IPR011068), Poly(A) polymerase, RNA-binding domain (InterPro:IPR007010); BEST Arabidopsis thaliana protein match is: poly(A) polymerase 2 (TAIR:AT2G25850.4); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      6187465..6191708 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101661.5 → NP_173240.2  poly(A) polymerase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173240.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4I948, Q9LMT2
      UniProtKB/TrEMBL
      A0A178W197, A0A5S9UX52, A0A7G2DRF2
      Conserved Domains (2) summary
      pfam04926
      Location:359 → 488
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:12 → 356
      PAP_central; Poly(A) polymerase central domain

    2. NM_202126.2 → NP_973855.1  poly(A) polymerase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973855.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2DRF2
      Conserved Domains (2) summary
      pfam04926
      Location:232 → 361
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:1 → 229
      PAP_central; Poly(A) polymerase central domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LMT2.1

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