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    Spa17 sperm autoantigenic protein 17 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85244, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Spa17provided by RGD
    Official Full Name
    sperm autoantigenic protein 17provided by RGD
    Primary source
    RGD:620154
    See related
    Ensembl:ENSRNOG00000010934 AllianceGenome:RGD:620154
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sp17
    Summary
    Predicted to enable calmodulin binding activity. Predicted to be involved in binding activity of sperm to zona pellucida. Predicted to be located in external side of plasma membrane and motile cilium. Predicted to be active in cytoplasm; sperm fibrous sheath; and sperm principal piece. Orthologous to human SPA17 (sperm autoantigenic protein 17). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 1241.3), Kidney (RPKM 78.8) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spa17 in Genome Data Viewer
    Location:
    8q22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (45496175..45507262, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (37307432..37318519, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (40066954..40078131, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693043 Neighboring gene uncharacterized LOC108351844 Neighboring gene sialic acid acetylesterase Neighboring gene transforming growth factor beta regulator 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cancer-testis antigens as biomarkers for Merkel cell carcinoma: Pitfalls and opportunities. Dasgeb B, et al. J Cutan Pathol, 2019 Oct. PMID 31218705, Free PMC Article
    2. Overexpression of human sperm protein 17 increases migration and decreases the chemosensitivity of human epithelial ovarian cancer cells. Li FQ, et al. BMC Cancer, 2009 Sep 11. PMID 19744347, Free PMC Article
    3. Sperm protein 17 is expressed in the sperm fibrous sheath. Chiriva-Internati M, et al. J Transl Med, 2009 Jul 15. PMID 19604394, Free PMC Article
    4. Sequence and localization of the mouse sperm autoantigenic protein, Sp17. Kong M, et al. Biol Reprod, 1995 Sep. PMID 7578682
    5. Characterization of Sp17: a ubiquitous three domain protein that binds heparin. Wen Y, et al. Biochem J, 2001 Jul 1. PMID 11415432, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in sperm fibrous sheath IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm fibrous sheath ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in sperm principal piece IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm principal piece ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sperm surface protein Sp17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053482.2 → NP_445934.1  sperm surface protein Sp17

      See identical proteins and their annotated locations for NP_445934.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6KRK5, F7FLV9, Q9Z1K2
      Related
      ENSRNOP00000014866.1, ENSRNOT00000014866.4
      Conserved Domains (3) summary
      smart00015
      Location:114 → 132
      IQ; Calmodulin-binding motif
      cd12100
      Location:12 → 50
      DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17
      cd22307
      Location:74 → 143
      Adgb_C_mid-like; C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted globin domain and IQ motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      45496175..45507262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595948.3 → XP_017451437.1  sperm surface protein Sp17 isoform X1

      UniProtKB/TrEMBL
      A6KRK5, F7FLV9, Q9Z1K2
      Conserved Domains (3) summary
      smart00015
      Location:114 → 132
      IQ; Calmodulin-binding motif
      cd12100
      Location:12 → 50
      DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17
      cd22307
      Location:74 → 143
      Adgb_C_mid-like; C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted globin domain and IQ motif
    Nucleotide Protein Strain
    Heading Accession and Version

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