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    Naxe NAD(P)HX epimerase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295229, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Naxeprovided by RGD
    Official Full Name
    NAD(P)HX epimeraseprovided by RGD
    Primary source
    RGD:1304699
    See related
    Ensembl:ENSRNOG00000019201 AllianceGenome:RGD:1304699
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    AI-BP; Apoa1bp
    Summary
    Enables NADHX epimerase activity and NADPHX epimerase activity. Predicted to be involved in several processes, including membrane raft distribution; negative regulation of angiogenesis; and regulation of cholesterol efflux. Predicted to be located in several cellular components, including cell body; cilium; and extracellular space. Predicted to be active in mitochondrion. Orthologous to human NAXE (NAD(P)HX epimerase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 164.4), Heart (RPKM 163.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Naxe in Genome Data Viewer
    Location:
    2q34
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (175816824..175818903, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (173518971..173521036, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (187424319..187426410, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene hyaluronan and proteoglycan link protein 2 Neighboring gene G patch domain containing 4 Neighboring gene tetratricopeptide repeat domain 24 Neighboring gene IQ motif containing GTPase activating protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. NAXE Mutations Disrupt the Cellular NAD(P)HX Repair System and Cause a Lethal Neurometabolic Disorder of Early Childhood. Kremer LS, et al. Am J Hum Genet, 2016 Oct 6. PMID 27616477, Free PMC Article
    2. Biochemical and structural characterization of apolipoprotein A-I binding protein, a novel phosphoprotein with a potential role in sperm capacitation. Jha KN, et al. Endocrinology, 2008 May. PMID 18202122, Free PMC Article
    3. Occurrence and subcellular distribution of the NADPHX repair system in mammals. Marbaix AY, et al. Biochem J, 2014 May 15. PMID 24611804
    4. Cloning and characterization of a novel apolipoprotein A-I binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I. Ritter M, et al. Genomics, 2002 May. PMID 11991719
    5. Control of angiogenesis by AIBP-mediated cholesterol efflux. Fang L, et al. Nature, 2013 Jun 6. PMID 23719382, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NADHX epimerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADHX epimerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NADPHX epimerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane raft distribution ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane raft distribution ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nicotinamide nucleotide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cholesterol efflux ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sprouting angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NAD(P)H-hydrate epimerase
    Names
    apolipoprotein A-I-binding protein
    NP_001386156.1
    XP_063137676.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399227.1 → NP_001386156.1  NAD(P)H-hydrate epimerase precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      B0BNM1
      Related
      ENSRNOP00000025986.2, ENSRNOT00000025986.4
      Conserved Domains (1) summary
      PLN03049
      Location:50 → 281
      PLN03049; pyridoxine (pyridoxamine) 5'-phosphate oxidase; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      175816824..175818903 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281606.1 → XP_063137676.1  NAD(P)H-hydrate epimerase isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106440.1: Suppressed sequence

      Description
      NM_001106440.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B0BNM1.1 GenPept UniProtKB/Swiss-Prot:B0BNM1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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