Parg poly (ADP-ribose) glycohydrolase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pargprovided by RGD
Official Full Name: poly (ADP-ribose) glycohydrolaseprovided by RGD
Primary source: RGD:620387
See related: Ensembl:ENSRNOG00000019978 AllianceGenome:RGD:620387
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables chromatin binding activity and poly(ADP-ribose) glycohydrolase activity. Involved in positive regulation of DNA repair. Located in chromatin and nucleus. Used to study brain infarction. Biomarker of borna disease. Orthologous to several human genes including BPHL (biphenyl hydrolase like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 282.5), Adrenal (RPKM 216.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p16

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (7442696..7550585)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (7436429..7544276)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (8350168..8457999)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The study reports the crystal structures of Parg and its complex with a substrate mimic that reveal an open substrate-binding site and a unique 'tyrosine clasp' enabling endoglycosidic cleavage of branched PAR chains.
Title: Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element.
PARG is expressed in the nuclear fraction of primary spermatocytes and in the post-nuclear fraction of round spermatids
Title: Poly(ADPR) polymerase-1 and poly(ADPR) glycohydrolase level and distribution in differentiating rat germinal cells.
poly(ADP-ribose)polymerase-1 and -2 and poly(ADP-ribose)glycohydrolase have key roles in germinal cells as key proteins in processes that sense and repair DNA damage as well as in the commitment to apoptosis following prolonged oxidative stress
Title: Dual role for poly(ADP-ribose)polymerase-1 and -2 and poly(ADP-ribose)glycohydrolase as DNA-repair and pro-apoptotic factors in rat germinal cells exposed to nitric oxide donors.
results suggest that poly (ADP-ribose) glycohydrolase(PARG) activity modulates the inflammatory response in ischemia/reperfusion and participates in end (target) organ damage under these conditions
Title: PARG activity mediates intestinal injury induced by splanchnic artery occlusion and reperfusion.

Submit: New GeneRIF Correction

General gene information

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Markers

d16rat107 (e-PCR)
- UniSTS:121119

RH128636 (e-PCR)
- UniSTS:211944

D16Chm58 (e-PCR)
- UniSTS:517866

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables poly(ADP-ribose) glycohydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables poly(ADP-ribose) glycohydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables poly(ADP-ribose) glycohydrolase activity	IEA Inferred from Electronic Annotation more info
enables poly(ADP-ribose) glycohydrolase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ATP generation from poly-ADP-D-ribose	IBA Inferred from Biological aspect of Ancestor more info
involved_in ATP generation from poly-ADP-D-ribose	IEA Inferred from Electronic Annotation more info
involved_in ATP generation from poly-ADP-D-ribose	ISO Inferred from Sequence Orthology more info
involved_in ATP generation from poly-ADP-D-ribose	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within detection of bacterium	ISO Inferred from Sequence Orthology more info
involved_in nucleotide-sugar metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA repair	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: poly(ADP-ribose) glycohydrolase

NP_112629.2

EC 3.2.1.143

XP_006252731.1

EC 3.2.1.143

XP_017455747.1

EC 3.2.1.143

XP_038950789.1

EC 3.2.1.143

XP_038950791.1

EC 3.2.1.143

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031339.2 → NP_112629.2 poly(ADP-ribose) glycohydrolase

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

Q9QYM2

UniProtKB/TrEMBL

A6KFW3, G3V8M8

Related

ENSRNOP00000027071.4, ENSRNOT00000027071.5

Conserved Domains (2) summary

pfam05028
Location:577 → 902

PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

NF033609
Location:181 → 398

MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

7442696..7550585

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017600258.3 → XP_017455747.1 poly(ADP-ribose) glycohydrolase isoform X2

UniProtKB/Swiss-Prot

Q9QYM2

UniProtKB/TrEMBL

A6KFW4

Conserved Domains (2) summary

pfam01439
Location:145 → 162

Metallothio_2; Metallothionein

pfam05028
Location:494 → 822

PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
XM_039094861.2 → XP_038950789.1 poly(ADP-ribose) glycohydrolase isoform X1

UniProtKB/Swiss-Prot

Q9QYM2

Conserved Domains (2) summary

pfam05028
Location:569 → 871

PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

NF033609
Location:181 → 398

MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA
XM_039094863.2 → XP_038950791.1 poly(ADP-ribose) glycohydrolase isoform X4

Conserved Domains (1) summary

NF033609
Location:181 → 398

MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA
XM_006252669.3 → XP_006252731.1 poly(ADP-ribose) glycohydrolase isoform X3

UniProtKB/Swiss-Prot

Q9QYM2

Conserved Domains (2) summary

pfam01439
Location:122 → 139

Metallothio_2; Metallothionein

pfam05028
Location:471 → 799

PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)