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    Gatad2a GATA zinc finger domain containing 2A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290669, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Gatad2aprovided by RGD
    Official Full Name
    GATA zinc finger domain containing 2Aprovided by RGD
    Primary source
    RGD:1310596
    See related
    Ensembl:ENSRNOG00000022173 AllianceGenome:RGD:1310596
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310596
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including blood vessel development; chordate embryonic development; and embryonic body morphogenesis. Predicted to be located in nucleoplasm. Predicted to be part of NuRD complex. Orthologous to human GATAD2A (GATA zinc finger domain containing 2A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 160.0), Adrenal (RPKM 152.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gatad2a in Genome Data Viewer
    Location:
    16p14
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (19463500..19553497)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (19429578..19520320)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (21177793..21267768)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene SURP and G patch domain containing 1 Neighboring gene MAU2 sister chromatid cohesion factor Neighboring gene testis-specific serine kinase 6 Neighboring gene NADH:ubiquinone oxidoreductase subunit A13 Neighboring gene YjeF N-terminal domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutants in the mouse NuRD/Mi2 component P66alpha are embryonic lethal. Marino S, et al. PLoS One, 2007 Jun 13. PMID 17565372, Free PMC Article
    2. Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3. Brackertz M, et al. J Biol Chem, 2002 Oct 25. PMID 12183469
    3. The nucleosome remodeling and deacetylase complex in development and disease. Basta J, et al. Transl Res, 2015 Jan. PMID 24880148, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109147

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior neuropore closure ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within blood vessel development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic body morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neural fold formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within programmed cell death ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of NuRD complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuRD complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcriptional repressor p66-alpha
    Names
    p66 alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013881.2 → NP_001013903.2  transcriptional repressor p66-alpha

      See identical proteins and their annotated locations for NP_001013903.2

      Status: PROVISIONAL

      Source sequence(s)
      CH474031
      UniProtKB/TrEMBL
      A6KA99
      Conserved Domains (2) summary
      pfam16563
      Location:133 → 169
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
      cl00158
      Location:417 → 450
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      19463500..19553497
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275203.1 → XP_063131273.1  transcriptional repressor p66-alpha isoform X6

    2. XM_017600035.3 → XP_017455524.1  transcriptional repressor p66-alpha isoform X2

      Conserved Domains (2) summary
      pfam16563
      Location:133 → 169
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
      cl29608
      Location:420 → 453
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

    3. XM_063275204.1 → XP_063131274.1  transcriptional repressor p66-alpha isoform X6

    4. XM_063275194.1 → XP_063131264.1  transcriptional repressor p66-alpha isoform X3

      UniProtKB/TrEMBL
      G3V8R7

    5. XM_063275205.1 → XP_063131275.1  transcriptional repressor p66-alpha isoform X7

    6. XM_063275199.1 → XP_063131269.1  transcriptional repressor p66-alpha isoform X4

      UniProtKB/TrEMBL
      A6KA99

    7. XM_039094339.2 → XP_038950267.1  transcriptional repressor p66-alpha isoform X2

      Conserved Domains (2) summary
      pfam16563
      Location:133 → 169
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
      cl29608
      Location:420 → 453
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

    8. XM_063275197.1 → XP_063131267.1  transcriptional repressor p66-alpha isoform X3

      UniProtKB/TrEMBL
      G3V8R7

    9. XM_063275207.1 → XP_063131277.1  transcriptional repressor p66-alpha isoform X8

    10. XM_063275202.1 → XP_063131272.1  transcriptional repressor p66-alpha isoform X5

    11. XM_063275200.1 → XP_063131270.1  transcriptional repressor p66-alpha isoform X5

    12. XM_063275192.1 → XP_063131262.1  transcriptional repressor p66-alpha isoform X2

    13. XM_017600034.3 → XP_017455523.1  transcriptional repressor p66-alpha isoform X2

      Conserved Domains (2) summary
      pfam16563
      Location:133 → 169
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
      cl29608
      Location:420 → 453
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

    14. XM_039094341.2 → XP_038950269.1  transcriptional repressor p66-alpha isoform X3

      UniProtKB/TrEMBL
      G3V8R7
      Related
      ENSRNOP00000027943.6
      Conserved Domains (2) summary
      pfam16563
      Location:133 → 169
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
      cl29608
      Location:419 → 452
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

    15. XM_039094342.2 → XP_038950270.1  transcriptional repressor p66-alpha isoform X5

      Conserved Domains (2) summary
      pfam16563
      Location:133 → 169
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
      cl29608
      Location:416 → 449
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

    16. XM_006252887.4 → XP_006252949.1  transcriptional repressor p66-alpha isoform X2

      See identical proteins and their annotated locations for XP_006252949.1

      Conserved Domains (2) summary
      pfam16563
      Location:133 → 169
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
      cl29608
      Location:420 → 453
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

    17. XM_039094340.2 → XP_038950268.1  transcriptional repressor p66-alpha isoform X2

      Conserved Domains (2) summary
      pfam16563
      Location:133 → 169
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
      cl29608
      Location:420 → 453
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

    18. XM_063275195.1 → XP_063131265.1  transcriptional repressor p66-alpha isoform X3

      UniProtKB/TrEMBL
      G3V8R7

    19. XM_063275198.1 → XP_063131268.1  transcriptional repressor p66-alpha isoform X4

      UniProtKB/TrEMBL
      A6KA99

    20. XM_063275201.1 → XP_063131271.1  transcriptional repressor p66-alpha isoform X5

    21. XM_063275193.1 → XP_063131263.1  transcriptional repressor p66-alpha isoform X2

    22. XM_063275190.1 → XP_063131260.1  transcriptional repressor p66-alpha isoform X1

    23. XM_063275208.1 → XP_063131278.1  transcriptional repressor p66-alpha isoform X9

    Nucleotide Protein Strain
    Heading Accession and Version

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