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    Unkl unk like zinc finger [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302987, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Unklprovided by RGD
    Official Full Name
    unk like zinc fingerprovided by RGD
    Primary source
    RGD:1565247
    See related
    Ensembl:ENSRNOG00000054605 AllianceGenome:RGD:1565247
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565247
    Summary
    Predicted to enable metal ion binding activity. Predicted to be located in cytosol. Orthologous to human UNKL (unk like zinc finger). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 53.7), Thymus (RPKM 51.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Unkl in Genome Data Viewer
    Location:
    10q12
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (14710627..14756725)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14206125..14252226)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (14547126..14593090)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein polypeptide C, pseudogene 3 Neighboring gene uncharacterized LOC120095050 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 4 Neighboring gene N-acetylglucosamine-1-phosphate transferase subunit gamma Neighboring gene TSR3 ribosome maturation factor Neighboring gene BAI1-associated protein 3 Neighboring gene microRNA 3547

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    putative E3 ubiquitin-protein ligase UNKL; unk like zinc finger
    Names
    unkempt family like zinc finger
    unkempt family zinc finger-like
    unkempt homolog-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430172.1 → NP_001417101.1  unk like zinc finger isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      D4A3S7

    2. NM_001430173.1 → NP_001417102.1  unk like zinc finger isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      14710627..14756725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270091.1 → XP_063126161.1  putative E3 ubiquitin-protein ligase UNKL isoform X9

    2. XM_006246057.4 → XP_006246119.1  putative E3 ubiquitin-protein ligase UNKL isoform X1

      Related
      ENSRNOP00000068992.1, ENSRNOT00000092043.2
      Conserved Domains (3) summary
      pfam00642
      Location:286 → 310
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam13863
      Location:564 → 638
      DUF4200; Domain of unknown function (DUF4200)
      pfam13920
      Location:684 → 721
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    3. XM_008767609.3 → XP_008765831.1  putative E3 ubiquitin-protein ligase UNKL isoform X4

      Conserved Domains (3) summary
      pfam00642
      Location:286 → 310
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam13863
      Location:488 → 562
      DUF4200; Domain of unknown function (DUF4200)
      pfam13920
      Location:608 → 645
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    4. XM_017597602.3 → XP_017453091.1  putative E3 ubiquitin-protein ligase UNKL isoform X2

    5. XM_017597603.3 → XP_017453092.1  putative E3 ubiquitin-protein ligase UNKL isoform X3

    6. XM_063270090.1 → XP_063126160.1  putative E3 ubiquitin-protein ligase UNKL isoform X6

      UniProtKB/TrEMBL
      A0A8I6G851

    7. XM_063270088.1 → XP_063126158.1  putative E3 ubiquitin-protein ligase UNKL isoform X5

    8. XM_063270089.1 → XP_063126159.1  putative E3 ubiquitin-protein ligase UNKL isoform X5

    9. XM_008767613.4 → XP_008765835.1  putative E3 ubiquitin-protein ligase UNKL isoform X7

      See identical proteins and their annotated locations for XP_008765835.1

      Conserved Domains (2) summary
      pfam13863
      Location:152 → 226
      DUF4200; Domain of unknown function (DUF4200)
      pfam13920
      Location:272 → 309
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    10. XM_006246059.5 → XP_006246121.1  putative E3 ubiquitin-protein ligase UNKL isoform X8

      See identical proteins and their annotated locations for XP_006246121.1

      UniProtKB/TrEMBL
      A0A8I6ARA8
      Related
      ENSRNOP00000097110.1
      Conserved Domains (2) summary
      pfam13920
      Location:196 → 233
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
      cl03075
      Location:76 → 173
      GrpE; nucleotide exchange factor GrpE
    Nucleotide Protein Strain
    Heading Accession and Version

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