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    Mkrn1 makorin ring finger protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296988, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Mkrn1provided by RGD
    Official Full Name
    makorin ring finger protein 1provided by RGD
    Primary source
    RGD:1303251
    See related
    Ensembl:ENSRNOG00000009280 AllianceGenome:RGD:1303251
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable chromatin binding activity and ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Orthologous to several human genes including MKRN1 (makorin ring finger protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 435.1), Testes (RPKM 287.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mkrn1 in Genome Data Viewer
    Location:
    4q23
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (69142710..69170211, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (68175908..68197216, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (67185167..67206478, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 37, member 3 Neighboring gene RAB19, member RAS oncogene family Neighboring gene small nucleolar RNA SNORA71 Neighboring gene DENN domain containing 2A Neighboring gene serine and arginine rich splicing factor 3, pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Makorin ring zinc finger protein 1 (MKRN1), a novel poly(A)-binding protein-interacting protein, stimulates translation in nerve cells. Miroci H, et al. J Biol Chem, 2012 Jan 6. PMID 22128154, Free PMC Article
    2. Identification of MKRN1 as a second E3 ligase for Eag1 potassium channels reveals regulation via differential degradation. Fang YC, et al. J Biol Chem, 2021 Jan-Jun. PMID 33647316, Free PMC Article
    3. Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis. Lee EW, et al. EMBO J, 2009 Jul 22. PMID 19536131, Free PMC Article
    4. Identification of potential nuclear reprogramming and differentiation factors by a novel selection method for cloning chromatin-binding proteins. Wang L, et al. Biochem Biophys Res Commun, 2004 Dec 3. PMID 15522233
    5. miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. Tarantino C, et al. FASEB J, 2010 Sep. PMID 20439489

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of MKRN1 as a second E3 ligase for Eag1 potassium channels reveals regulation via differential degradation.
      Title: Identification of MKRN1 as a second E3 ligase for Eag1 potassium channels reveals regulation via differential degradation.
    2. in mammalian neurons MKRN1-short interacts with PABP to locally control the translation of dendritic mRNAs at synapses.
      Title: Makorin ring zinc finger protein 1 (MKRN1), a novel poly(A)-binding protein-interacting protein, stimulates translation in nerve cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94941

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase makorin-1
    NP_001004233.1
    NP_001385662.1
    XP_006236364.1
    XP_006236365.1
    XP_006236366.1
    XP_063141820.1
    XP_063141821.1
    XP_063141822.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004233.2 → NP_001004233.1  E3 ubiquitin-protein ligase makorin-1 isoform 2

      See identical proteins and their annotated locations for NP_001004233.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IEV0, G3V789, Q68FR1
      Conserved Domains (2) summary
      smart00356
      Location:88 → 110
      ZnF_C3H1; zinc finger
      cd00162
      Location:281 → 323
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    2. NM_001398733.1 → NP_001385662.1  E3 ubiquitin-protein ligase makorin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A0G2QC40, A6IEU8
      Related
      ENSRNOP00000013124.4, ENSRNOT00000013124.6
      Conserved Domains (5) summary
      PHA03096
      Location:221 → 370
      PHA03096; p28-like protein; Provisional
      cd16730
      Location:278 → 338
      RING-HC_MKRN1_3; RING finger, HC subclass, found in makorin-1 (MKRN1), makorin-3 (MKRN3), and similar proteins
      pfam15815
      Location:392 → 481
      MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal
      pfam18044
      Location:59 → 80
      zf-CCCH_4; CCCH-type zinc finger
      pfam18345
      Location:90 → 108
      zf_CCCH_4; Zinc finger domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      69142710..69170211 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236302.5 → XP_006236364.1  E3 ubiquitin-protein ligase makorin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ALB9
      Related
      ENSRNOP00000089576.1
      Conserved Domains (3) summary
      PHA03096
      Location:178 → 327
      PHA03096; p28-like protein; Provisional
      cd00162
      Location:238 → 292
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam15815
      Location:357 → 436
      MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal

    2. XM_006236304.5 → XP_006236366.1  E3 ubiquitin-protein ligase makorin-1 isoform X2

      See identical proteins and their annotated locations for XP_006236366.1

      UniProtKB/TrEMBL
      A0A8I6B298
      Conserved Domains (4) summary
      smart00356
      Location:24 → 46
      ZnF_C3H1; zinc finger
      PHA03096
      Location:157 → 306
      PHA03096; p28-like protein; Provisional
      cd00162
      Location:217 → 271
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam15815
      Location:336 → 415
      MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal

    3. XM_006236303.5 → XP_006236365.1  E3 ubiquitin-protein ligase makorin-1 isoform X2

      See identical proteins and their annotated locations for XP_006236365.1

      UniProtKB/TrEMBL
      A0A8I6B298
      Conserved Domains (4) summary
      smart00356
      Location:24 → 46
      ZnF_C3H1; zinc finger
      PHA03096
      Location:157 → 306
      PHA03096; p28-like protein; Provisional
      cd00162
      Location:217 → 271
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam15815
      Location:336 → 415
      MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal

    4. XM_063285750.1 → XP_063141820.1  E3 ubiquitin-protein ligase makorin-1 isoform X3

    5. XM_063285752.1 → XP_063141822.1  E3 ubiquitin-protein ligase makorin-1 isoform X5

    6. XM_063285751.1 → XP_063141821.1  E3 ubiquitin-protein ligase makorin-1 isoform X4

      UniProtKB/TrEMBL
      A6IEV1
    Nucleotide Protein Strain
    Heading Accession and Version

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