Micu1 mitochondrial calcium uptake 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Micu1provided by RGD
Full Name: mitochondrial calcium uptake 1provided by RGD
Primary source: RGD:735033
See related: Ensembl:ENSRNOG00000043436 AllianceGenome:RGD:735033
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cbara1
Summary: Predicted to enable calcium ion binding activity; identical protein binding activity; and protein heterodimerization activity. Predicted to be involved in several processes, including calcium import into the mitochondrion; positive regulation of mitochondrial calcium ion concentration; and regulation of cellular hyperosmotic salinity response. Predicted to be located in mitochondrial inner membrane and mitochondrial intermembrane space. Predicted to be integral component of mitochondrial membrane. Predicted to be part of uniplex complex. Human ortholog(s) of this gene implicated in myopathy with extrapyramidal signs. Orthologous to human MICU1 (mitochondrial calcium uptake 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 228.9), Lung (RPKM 175.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (28211774..28357928)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (27668681..27816322)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (29284833..29433617)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In vitro data show that the reconstitution of MICU1 inhibited the apoptosis of cardiomyocytes, induced by high glucose and high fat, through increasing mitochondrial Ca(2+) uptake and subsequently activating the antioxidant system.
Title: MICU1 Alleviates Diabetic Cardiomyopathy Through Mitochondrial Ca(2+)-Dependent Antioxidant Response.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel inhibitor activity	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion sensor activity	ISO Inferred from Sequence Orthology more info
enables calcium ion sensor activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium import into the mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium import into the mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in calcium import into the mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in calcium import into the mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium ion import	IEA Inferred from Electronic Annotation more info
involved_in calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in calcium ion import	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial calcium ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial calcium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cristae formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cristae formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitochondrial calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitochondrial calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular hyperosmotic salinity response	IEA Inferred from Electronic Annotation more info
involved_in regulation of cellular hyperosmotic salinity response	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular hyperosmotic salinity response	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of calcium channel complex	ISO Inferred from Sequence Orthology more info
part_of calcium channel complex	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial crista junction	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info
located_in mitochondrial intermembrane space	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of uniplex complex	IBA Inferred from Biological aspect of Ancestor more info
part_of uniplex complex	IEA Inferred from Electronic Annotation more info
part_of uniplex complex	ISO Inferred from Sequence Orthology more info
part_of uniplex complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: calcium uptake protein 1, mitochondrial

Names: calcium binding atopy-related autoantigen 1; calcium-binding atopy-related autoantigen 1 homolog; calcium-binding atopy-related autoantigen 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199412.2 → NP_955444.2 calcium uptake protein 1, mitochondrial

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

Q6P6Q9

Related

ENSRNOP00000094895.1, ENSRNOT00000101745.1

Conserved Domains (1) summary

cd16173
Location:224 → 443

EFh_MICU1; EF-hand, calcium binding motif, found in calcium uptake protein 1, mitochondrial (MICU1) and similar proteins