Ppa1 inorganic pyrophosphatase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppa1provided by RGD
Official Full Name: inorganic pyrophosphatase 1provided by RGD
Primary source: RGD:1589773
See related: Ensembl:ENSRNOG00000063854 AllianceGenome:RGD:1589773
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pp; Pyp
Summary: Predicted to enable pyrophosphatase activity. Predicted to be involved in phosphate-containing compound metabolic process. Predicted to be located in cytoplasm. Orthologous to human PPA1 (inorganic pyrophosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 487.9), Heart (RPKM 307.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (30132088..30160492)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (29590733..29617711)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (31265519..31292451)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

There is an age-associated increase (approximately 2-fold) in the expression of rat liver cytosolic iPPase gene by differential display PCR and northern blot analysis.
Title: Age-dependent differential expression and activity of rat liver cytosolic inorganic pyrophosphatase gene.
Cloning, expression, and functional analysis of rat liver cytosolic Pyp gene and characterization of its functional promoter are reported.
Title: Cloning, expression, and functional analysis of rat liver cytosolic inorganic pyrophosphatase gene and characterization of its functional promoter.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables inorganic diphosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables pyrophosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in COPII vesicle coating	IEA Inferred from Electronic Annotation more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in phosphate-containing compound metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inorganic pyrophosphatase

Names: pyrophosphatase (inorganic) 1; pyrophosphatase 1

NP_001094304.1

EC 3.6.1.1

XP_038954538.1

EC 3.6.1.1

XP_063135139.1

EC 3.6.1.1

XP_063135140.1

EC 3.6.1.1

XP_063135141.1

EC 3.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100834.1 → NP_001094304.1 inorganic pyrophosphatase

Status: VALIDATED

Source sequence(s)

BC099794

UniProtKB/TrEMBL

F7EPH4

Related

ENSRNOP00000000674.6, ENSRNOT00000000674.7

Conserved Domains (1) summary

cl00217
Location:2 → 241

pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

30132088..30160492

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063279070.1 → XP_063135140.1 inorganic pyrophosphatase isoform X3

UniProtKB/TrEMBL

F7EPH4
XM_063279069.1 → XP_063135139.1 inorganic pyrophosphatase isoform X2

UniProtKB/TrEMBL

F7EPH4
XM_039098610.2 → XP_038954538.1 inorganic pyrophosphatase isoform X1

UniProtKB/TrEMBL

A0A0G2JUD2, F7EPH4

Related

ENSRNOP00000069053.2

Conserved Domains (1) summary

cl00217
Location:2 → 263

pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.
XM_063279071.1 → XP_063135141.1 inorganic pyrophosphatase isoform X4

UniProtKB/TrEMBL

A0A8I6GET1, F7EPH4