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    Sh2d4a SH2 domain containing 4A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306376, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Sh2d4aprovided by RGD
    Official Full Name
    SH2 domain containing 4Aprovided by RGD
    Primary source
    RGD:1307991
    See related
    Ensembl:ENSRNOG00000013541 AllianceGenome:RGD:1307991
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatase binding activity. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human SH2D4A (SH2 domain containing 4A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 288.9), Lung (RPKM 263.4) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sh2d4a in Genome Data Viewer
    Location:
    16p14
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (26106721..26176069, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (21339010..21409360, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (23084247..23156825, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene chondroitin sulfate N-acetylgalactosaminyltransferase 1 Neighboring gene splicing factor YJU2-like Neighboring gene uncharacterized LOC120097455 Neighboring gene uncharacterized LOC134482490 Neighboring gene uncharacterized LOC102551750

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression and subcellular distribution of novel glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and 2310066E14Rik. Patrakka J, et al. J Am Soc Nephrol, 2007 Mar. PMID 17251388
    2. Docking motif-guided mapping of the interactome of protein phosphatase-1. Hendrickx A, et al. Chem Biol, 2009 Apr 24. PMID 19389623
    3. The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis. Li ZZ, et al. Biosci Rep, 2020 Jan 31. PMID 31904090, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SH2 domain-containing protein 4A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012048.1 → NP_001012048.1  SH2 domain-containing protein 4A

      See identical proteins and their annotated locations for NP_001012048.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079100
      UniProtKB/Swiss-Prot
      Q6AYC8
      UniProtKB/TrEMBL
      A0A8I5ZXE8
      Related
      ENSRNOP00000018543.3, ENSRNOT00000018543.6
      Conserved Domains (2) summary
      PTZ00121
      Location:32 → 243
      PTZ00121; MAEBL; Provisional
      cd10350
      Location:308 → 410
      SH2_SH2D4A; Src homology 2 domain found in the SH2 domain containing protein 4A (SH2D4A)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      26106721..26176069 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094496.2 → XP_038950424.1  SH2 domain-containing protein 4A isoform X1

      UniProtKB/Swiss-Prot
      Q6AYC8
      UniProtKB/TrEMBL
      A0A8I5ZXE8
      Conserved Domains (2) summary
      PTZ00121
      Location:32 → 243
      PTZ00121; MAEBL; Provisional
      cd10350
      Location:308 → 410
      SH2_SH2D4A; Src homology 2 domain found in the SH2 domain containing protein 4A (SH2D4A)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYC8.1 GenPept UniProtKB/Swiss-Prot:Q6AYC8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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