Fgf12 fibroblast growth factor 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Fgf12provided by RGD
Full Name: fibroblast growth factor 12provided by RGD
Primary source: RGD:620163
See related: Ensembl:ENSRNOG00000001931 AllianceGenome:RGD:620163
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fhf1; Fgf1a; Fhf1b
Summary: Enables sodium channel regulator activity and transmembrane transporter binding activity. Involved in negative regulation of cation channel activity; regulation of membrane depolarization; and regulation of sodium ion transmembrane transporter activity. Predicted to be located in synapse. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 47. Orthologous to human FGF12 (fibroblast growth factor 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 421.1), Heart (RPKM 185.9) and 1 other tissue See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 11q22

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (85501947..86069543)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (71997151..72564757)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (75606360..76171078)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-107 Aggravates Oxygen-Glucose Deprivation/Reoxygenation (OGD/R)-Induced Injury Through Inactivating PI3K-AKT Signalling Pathway by Targeting FGF9/FGF12 in PC12 Cells.
Title: MiR-107 Aggravates Oxygen-Glucose Deprivation/Reoxygenation (OGD/R)-Induced Injury Through Inactivating PI3K-AKT Signalling Pathway by Targeting FGF9/FGF12 in PC12 Cells.
FGF12 strongly induced the quiescent and contractile vascular smooth muscle cell phenotype and directly promoted VSMC lineage differentiation.
Title: Fibroblast Growth Factor 12 Is a Novel Regulator of Vascular Smooth Muscle Cell Plasticity and Fate.
Fibroblast growth factor 12 is a component of the voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in the rat brain.
Title: Quantitative proteomics reveals protein-protein interactions with fibroblast growth factor 12 as a component of the voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in Mammalian brain.
Sodium channels in Fhf1-/-Fhf4-/- granule neurons inactivate at more negative membrane potential, inactivate more rapidly, and are slower to recover from the inactivated state.
Title: Fibroblast growth factor homologous factors control neuronal excitability through modulation of voltage-gated sodium channels.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

RH140156 (e-PCR)
- UniSTS:222235

BF397888 (e-PCR)
- UniSTS:246352

RH140530 (e-PCR)
- UniSTS:222599

D11Arb13 (e-PCR)
- UniSTS:240286

D11Mco1 (e-PCR)
- UniSTS:239293

RH142893 (e-PCR)
- UniSTS:232140

AU027386 (e-PCR)
- UniSTS:113358

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables fibroblast growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sodium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within JNK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult locomotory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane depolarization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neuronal action potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuronal action potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuronal action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of sodium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of voltage-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: fibroblast growth factor 12

Names: FGF-12; FHF-1; fibroblast growth factor 1a; fibroblast growth factor homologous factor 1; fibroblast growth factor homologous factor 1b

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395084.1 → NP_001382013.1 fibroblast growth factor 12 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A6JRX5, A6JRX6

Related

ENSRNOP00000002650.2, ENSRNOT00000002650.5

Conserved Domains (1) summary

pfam00167
Location:12 → 136

FGF; Fibroblast growth factor
NM_130814.2 → NP_570827.2 fibroblast growth factor 12 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

P61150

UniProtKB/TrEMBL

A0A7U3L6G2

Conserved Domains (1) summary

pfam00167
Location:74 → 198

FGF; Fibroblast growth factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

85501947..86069543

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017597854.3 → XP_017453343.1 fibroblast growth factor 12 isoform X1

UniProtKB/TrEMBL

A0A8I6A2F9, A6JRX6

Related

ENSRNOP00000085066.1

Conserved Domains (1) summary

pfam00167
Location:38 → 162

FGF; Fibroblast growth factor