Zc3h15 zinc finger CCCH-type containing 15 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zc3h15provided by RGD
Official Full Name: zinc finger CCCH-type containing 15provided by RGD
Primary source: RGD:1359234
See related: Ensembl:ENSRNOG00000005256 AllianceGenome:RGD:1359234
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable metal ion binding activity. Predicted to be involved in cytoplasmic translation and positive regulation of GTPase activity. Predicted to act upstream of or within cytokine-mediated signaling pathway. Predicted to be located in nucleus. Predicted to be active in cytosol. Orthologous to human ZC3H15 (zinc finger CCCH-type containing 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 389.5), Brain (RPKM 307.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q24

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (89151432..89171203)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (68744591..68764335)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (71020420..71040159)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

p48ZnF' cellular location of action depends on the cell's differentiation status: nuclear in proliferating cells and cytoplasmic in differentiated neurons.
Title: Establishing an in vivo p48ZnF bioluminescence mouse brain imaging model.
p48ZnF is up-regulated in rat neuronal PC12 cells upon stimulation with the neurotrophic factor NGF
Title: Nerve growth factor (NGF) induces mRNA expression of the new transcription factor protein p48ZnF.

Submit: New GeneRIF Correction

General gene information

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Markers

DXS9848 (e-PCR)
- UniSTS:474256

RH140856 (e-PCR)
- UniSTS:222890

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger CCCH domain-containing protein 15

Names: brain zinc finger protein; p48ZnF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001010963.1 → NP_001010963.1 zinc finger CCCH domain-containing protein 15

See identical proteins and their annotated locations for NP_001010963.1

Status: PROVISIONAL

Source sequence(s)

BC088438

UniProtKB/Swiss-Prot

Q6U6G5

UniProtKB/TrEMBL

A0A8I6GIP0, A6HMP1

Related

ENSRNOP00000007276.4, ENSRNOT00000007276.6

Conserved Domains (3) summary

smart00356
Location:99 → 125

ZnF_C3H1; zinc finger

COG5252
Location:1 → 325

COG5252; Uncharacterized conserved protein, contains CCCH-type Zn-finger protein [General function prediction only]

pfam16543
Location:230 → 312

DFRP_C; DRG Family Regulatory Proteins, Tma46