Asgr2 asialoglycoprotein receptor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Asgr2provided by RGD
Official Full Name: asialoglycoprotein receptor 2provided by RGD
Primary source: RGD:2161
See related: Ensembl:ENSRNOG00000030726 AllianceGenome:RGD:2161
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable carbohydrate binding activity. Involved in bone mineralization. Predicted to be located in endoplasmic reticulum quality control compartment and perinuclear region of cytoplasm. Predicted to be active in external side of plasma membrane. Orthologous to human ASGR2 (asialoglycoprotein receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 897.1) and Heart (RPKM 34.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (55320082..55333294)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (54821407..54834624)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (56710446..56723608)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fucose binding	IBA Inferred from Biological aspect of Ancestor more info
enables mannose binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological process involved in interspecies interaction between organisms	IBA Inferred from Biological aspect of Ancestor more info
involved_in bone mineralization	IEP Inferred from Expression Pattern more info	PubMed
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycoprotein metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein stability	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum quality control compartment	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: asialoglycoprotein receptor 2

Names: ASGP-R 2; ASGPR 2; HL-2; RHL-2; hepatic lectin 2, RHL2; hepatic lectin R2/3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017189.3 → NP_058885.1 asialoglycoprotein receptor 2

See identical proteins and their annotated locations for NP_058885.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

P08290, Q5M8C9

UniProtKB/TrEMBL

A6HG21

Related

ENSRNOP00000060474.1, ENSRNOT00000065370.4

Conserved Domains (2) summary

cd03590
Location:170 → 295

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

pfam03954
Location:29 → 162

Lectin_N; Hepatic lectin, N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

55320082..55333294

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006246676.5 → XP_006246738.1 asialoglycoprotein receptor 2 isoform X1

See identical proteins and their annotated locations for XP_006246738.1

UniProtKB/Swiss-Prot

P08290, Q5M8C9

UniProtKB/TrEMBL

A6HG21

Conserved Domains (2) summary

cd03590
Location:170 → 295

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

pfam03954
Location:29 → 162

Lectin_N; Hepatic lectin, N-terminal domain