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    Lpin3 lipin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362261, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Lpin3provided by RGD
    Official Full Name
    lipin 3provided by RGD
    Primary source
    RGD:1588534
    See related
    Ensembl:ENSRNOG00000016636 AllianceGenome:RGD:1588534
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidate phosphatase activity and transcription coactivator activity. Predicted to be involved in several processes, including cellular response to insulin stimulus; fatty acid catabolic process; and triglyceride biosynthetic process. Predicted to be active in nucleus. Orthologous to human LPIN3 (lipin 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 71.5), Kidney (RPKM 67.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lpin3 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (169953479..169978034)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (149533719..149558494)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (156874805..156899601)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene DNA topoisomerase I Neighboring gene uncharacterized LOC102551164 Neighboring gene phospholipase C, gamma 1 Neighboring gene zinc fingers and homeoboxes 3 Neighboring gene uncharacterized LOC134486198 Neighboring gene elastin microfibril interfacer 3 Neighboring gene uncharacterized LOC134486200 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene chromodomain helicase DNA binding protein 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Differential regulation of the expressions of the PGC-1α splice variants, lipins, and PPARα in heart compared to liver. Kok BPC, et al. J Lipid Res, 2013 Jun. PMID 23505321, Free PMC Article
    2. Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns. Donkor J, et al. J Biol Chem, 2007 Feb 9. PMID 17158099
    3. Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2. Grimsey N, et al. J Biol Chem, 2008 Oct 24. PMID 18694939, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109016

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to insulin stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in triglyceride biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidate phosphatase LPIN3
    NP_001014206.1
    XP_006235549.1
    XP_006235555.1
    XP_038961442.1
    XP_038961443.1
    XP_038961444.1
    XP_038961445.1
    XP_038961447.1
    XP_038961449.1
    XP_063140260.1
    XP_063140262.1
    XP_063140263.1
    XP_063140264.1
    XP_063140265.1
    XP_063140266.1
    XP_063140267.1
    XP_063140268.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014184.1 → NP_001014206.1  phosphatidate phosphatase LPIN3

      See identical proteins and their annotated locations for NP_001014206.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089878
      UniProtKB/TrEMBL
      A0A8J8YGA4, F1LMI0, Q5EBA5
      Conserved Domains (3) summary
      pfam04571
      Location:1 → 106
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:585 → 810
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:431 → 521
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      169953479..169978034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284190.1 → XP_063140260.1  phosphatidate phosphatase LPIN3 isoform X1

    2. XM_039105515.2 → XP_038961443.1  phosphatidate phosphatase LPIN3 isoform X1

      UniProtKB/TrEMBL
      A0A8J8YGA4
      Conserved Domains (3) summary
      pfam04571
      Location:1 → 107
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:586 → 811
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:432 → 523
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    3. XM_039105519.2 → XP_038961447.1  phosphatidate phosphatase LPIN3 isoform X1

      UniProtKB/TrEMBL
      A0A8J8YGA4
      Conserved Domains (3) summary
      pfam04571
      Location:1 → 107
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:586 → 811
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:432 → 523
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    4. XM_039105521.2 → XP_038961449.1  phosphatidate phosphatase LPIN3 isoform X1

      UniProtKB/TrEMBL
      A0A8J8YGA4
      Conserved Domains (3) summary
      pfam04571
      Location:1 → 107
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:586 → 811
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:432 → 523
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    5. XM_063284193.1 → XP_063140263.1  phosphatidate phosphatase LPIN3 isoform X2

      UniProtKB/TrEMBL
      F1LMI0, Q5EBA5

    6. XM_063284197.1 → XP_063140267.1  phosphatidate phosphatase LPIN3 isoform X2

      UniProtKB/TrEMBL
      F1LMI0, Q5EBA5

    7. XM_006235493.5 → XP_006235555.1  phosphatidate phosphatase LPIN3 isoform X2

      See identical proteins and their annotated locations for XP_006235555.1

      UniProtKB/TrEMBL
      A0A8J8YGA4, F1LMI0, Q5EBA5
      Conserved Domains (3) summary
      pfam04571
      Location:1 → 106
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:585 → 810
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:431 → 521
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    8. XM_039105517.2 → XP_038961445.1  phosphatidate phosphatase LPIN3 isoform X1

      UniProtKB/TrEMBL
      A0A8J8YGA4
      Conserved Domains (3) summary
      pfam04571
      Location:1 → 107
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:586 → 811
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:432 → 523
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    9. XM_063284195.1 → XP_063140265.1  phosphatidate phosphatase LPIN3 isoform X2

      UniProtKB/TrEMBL
      F1LMI0, Q5EBA5

    10. XM_063284192.1 → XP_063140262.1  phosphatidate phosphatase LPIN3 isoform X1

    11. XM_063284196.1 → XP_063140266.1  phosphatidate phosphatase LPIN3 isoform X2

      UniProtKB/TrEMBL
      F1LMI0, Q5EBA5

    12. XM_063284198.1 → XP_063140268.1  phosphatidate phosphatase LPIN3 isoform X3

    13. XM_039105516.2 → XP_038961444.1  phosphatidate phosphatase LPIN3 isoform X1

      UniProtKB/TrEMBL
      A0A8J8YGA4
      Conserved Domains (3) summary
      pfam04571
      Location:1 → 107
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:586 → 811
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:432 → 523
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    14. XM_039105514.2 → XP_038961442.1  phosphatidate phosphatase LPIN3 isoform X1

      UniProtKB/TrEMBL
      A0A8J8YGA4
      Conserved Domains (3) summary
      pfam04571
      Location:1 → 107
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:586 → 811
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:432 → 523
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    15. XM_063284194.1 → XP_063140264.1  phosphatidate phosphatase LPIN3 isoform X2

      UniProtKB/TrEMBL
      F1LMI0, Q5EBA5

    16. XM_006235487.5 → XP_006235549.1  phosphatidate phosphatase LPIN3 isoform X2

      See identical proteins and their annotated locations for XP_006235549.1

      UniProtKB/TrEMBL
      A0A8J8YGA4, F1LMI0, Q5EBA5
      Related
      ENSRNOP00000096250.1
      Conserved Domains (3) summary
      pfam04571
      Location:1 → 106
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:585 → 810
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:431 → 521
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    RNA

    1. XR_010064668.1 RNA Sequence

    2. XR_010064667.1 RNA Sequence

    3. XR_010064666.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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